推拉效应对心血管系统影响的建模仿真研究  

Modeling and simulation for cardiovascular effect induced by push-pull effect

作　　者：李毅[1] 陆庆国[1] 邢楠[1] 邹志国[1] 刘洋[1] 冯娜[2] 张曦[1] 常小红[1] 卢虹冰[1] 

机构地区：[1]第四军医大学生物医学工程学院,西安710032 [2]第四军医大学基础部生理学教研室,西安710032

出　　处：《医疗卫生装备》2015年第4期12-15,共4页Chinese Medical Equipment Journal

基　　金：军队医学科技青年培育项目(13QNP126)

摘　　要：目的:建立可仿真推拉效应引起人体心血管变化的、非线性分布式人体心血管系统模型,并通过与真实实验数据对比,验证模型的有效性。方法:在分析推拉效应对心血管系统影响的基础上,对模型进行设计,并利用Pascal语言,建立一个将心脏、血管系统和反馈机制相结合的闭环心血管系统模型。结果:建立的分布式模型包括左、右心室和心房4腔室,大中动、静脉血管各22段,中小动、静脉等外周血管12段,并包含颈动脉压力调节和静脉塌陷模型。仿真结果与报道的人体旋转床和离心机实验数据相近。结论:该模型可以有效地模拟飞行员做推拉动作时心血管系统的响应,为推拉效应的研究提出了一个经济、实用的方法。Objective To develop a nonlinear and distributed cardiovascular system model, which can simulate the cardiovascular effect induced by push-pull effect（PPE）. Methods The model was designed based on the analysis of the effect of PPE on cardiovascular system. Programmed with Pascal language, the closed-loop model was combined with heart, vessels and baroreflex regulation. Results The developed model consisted of left and right ventricles and atria, 22 segments of arteries and veins, 12 segments of peripheral vascular beds, carotid blood pressure regulation, and vein collapse model. The simulation results compared well with reported data from tilt-table and centrifuge experiment.Conclusion The model can simulate the cardiovascular response to push-pull maneuver and may be an economical and practical method to investigating PPE.

关 键 词：推拉效应 心血管系统 建模 仿真 

分 类 号：R318[医药卫生—生物医学工程] TP391.9[医药卫生—基础医学]