两种不同证型2型糖尿病患者胰岛功能差异性研究  

Study on Differences in Islet Functions between Two Different TCM Syndromes of T2DM

作　　者：张洪艳[1,2] 孙永宁[2] 

机构地区：[1]成都中医药大学,四川成都610075 [2]上海交通大学附属第六人民医院,上海200233

出　　处：《辽宁中医杂志》2015年第4期682-684,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家中医药管理局中医临床研究基地建设项目(JDZX2012129);上海市科委医学引导(中医类)基金支助项目(12401905000)

摘　　要：目的:探讨气阴两虚证与痰湿内蕴证2型糖尿病患者胰岛功能的差异。方法:选取两种证型2型糖尿病患者84例,测量身高、体重、腰围、臀围,计算体重指数(BMI=体重(KG)/身高2(m2)。禁食8 h测定空腹血糖、空腹C肽、血脂、糖化血红蛋白(HBA1C)、糖化血清白蛋白(GA)、丙氨酸转移酶(ALT)等。测定餐后30 min血糖,餐后120 min血糖、餐后30 min C肽、餐后120 min C肽,并计算C肽的增量(△Cp30、△Cp120)。所有糖尿病患者行精氨酸试验,测定Cp指数及胰岛素指数。结果:痰湿内蕴组患者体重指数较大(P<0.05),收缩压较高(P<0.01),甘油三酯水平较高(P<0.05),ALT水平较低(P<0.05),尿酸水平高(P<0.05)。空腹血糖及餐后2 h血糖两组间差异有统计学意义(分别为P<0.05,P<0.01),餐后120 min C肽与120 min C肽增量差异两组相比差异有统计学意义(P<0.05)。Cp指数与胰岛素指数气阴两虚组优于痰湿内蕴组,差异均有统计学意义(P<0.05)结论:气阴两虚证组与痰湿内蕴证两组2型糖尿病患者胰岛功能有显著差异,气阴两虚组胰岛功能优于湿浊内蕴组。Objective：To explore the difference of islet functions between qi-yin deficiency syndrome group and internal damp and phlegm syndrome group in type 2 diabetes mellitus.Methods：84 cases of type 2 diabetes patients with qi-yin deficiency syndrome and internal damp and phlegm syndrome were selected to measure height,weight,waist circumference,hip circumference and body mass index（BMI）.Fasting blood glucose,fasting c-peptide,blood lipids,glycosylated hemoglobin（HBA1C）,glycated albumin（GA） and alanine transferase（ALT） were determined.Meanwhile,30 min postprandial blood glucose and C-peptide,12 0min postprandial blood glucose and C-peptide were measured and increases of C-peptide（△Cp30,△Cp120） were calculated.Moreover,arginine test was taken by all patients to measure C-peptide index and insulin index reflecting islet β cell function.Results：The patients in internal damp and phlegm syndrome had lager BMI（P〈0.05）,higher diastolic pressure（P〈0.01）,higher triglycercide（P〈0.05）,lower ALT（P〈0.05） and higher uric acid（P〈0.05） than those of the other group.And there were significant differences in 30 min postprandial glucose and 120 min postprandial glucose between two groups（P〈0.05,P〈0.01 respectively）.Furthermore,Cp index and insulin index of patients in qi-yin deficiency group were better than those in internal damp and phlegm group（P〈0.05）.Conclusion：There is significant difference in islet functions between the two groups and islet function in qi-yin deficiency group is better than that in internal damp and phlegm group.

关 键 词：2型糖尿病 气阴两虚 痰湿内蕴 胰岛功能 

分 类 号：R587.1[医药卫生—内分泌]