卡介苗(BCG)感染对U937细胞系蛋白质乙酰化水平的影响  

The Effect of BCG Infection on the Level of Protein Acetylation in U937 Cell Lines

作　　者：李苗[1] 罗恩杰[1] 

机构地区：[1]中国医科大学基础医学院病原生物学教研室,辽宁沈阳110001

出　　处：《微生物学杂志》2015年第1期46-48,共3页Journal of Microbiology

基　　金：国家自然科学基金资助项目(81201333)

摘　　要：研究卡介苗(BCG)感染对U937细胞系蛋白质乙酰化水平的影响。构建U937巨噬细胞模型,感染BCG后提取细胞总蛋白,western blot方法检测细胞总蛋白乙酰化水平的改变。结果表明,在分化成熟的U937细胞系中,BCG感染能够上调蛋白质乙酰化水平,引起表观遗传学的改变。The effect of BCG infection on protein acetylation level in U937 cell lines was studied. U937 macrophage model was constructed,and then total cellular protein was extracted after infected with BCG. Western blot was used to detect the changes of total protein acetylation level. The results showed that the BCG infection upregulated the protein acetylation level in matured differentiated U937 cells,and caused in epigenetic changes.

关 键 词：卡介苗(BCG) U937 乙酰化 

分 类 号：Q939.93[生物学—微生物学] R379.911[医药卫生—病原生物学]