老年葡萄球菌感染肺炎去甲万古霉素治疗的血药浓度监测及意义  

Therapeutic drug monitoring of norvancomycin and rational drug use behavior analysis on elderly pneumonia patients with staphylococcal infections

作　　者：张琦[1] 赵文萃[1] 

机构地区：[1]解放军第208医院药剂科,长春130000

出　　处：《空军医学杂志》2015年第1期45-48,共4页Medical Journal of Air Force

基　　金：国家自然科学基金(81173559)

摘　　要：目的分析与探讨老年葡萄球菌感染肺炎应用去甲万古霉素后血药浓度监测指导临床合理用药的价值。方法选取我院收治的葡萄球菌肺炎80例,根据年龄将其分为2组,老年组50例,中青年组30例。给予去甲万古霉素进行静脉滴注,治疗3 d后对其血药浓度进行监测,并根据监测结果调整给药方式与给药剂量以指导临床合理用药。比较调整前后血肌酐水平与血尿素氮水平。结果老年组应用去甲万古霉素后的血药浓度变化与中青年组相比差异有统计学意义(P<0.05)。调整给药方式与给药剂量后,血肌酐与血尿氮素水平均趋于稳定。结论老年患者使用去甲万古霉素进行治疗过程中监测血药浓度能够有效指导合理用药,降低药物损害。Objective To analyze and investigate elderly patients norepinephrine guide rational drug use behavior after the value oftherapeutic drug monitoring ofvancomycin. Methods A total of80 cases ofpatients with pneumonia in our hospital from August 2013 to August 2014 were divided into two groups according to age ： the older group had 50 cases, the young group had 30 cases. Patients were given int ravenous vancomycin t reat ment monitor ing its blood concentration after 3 d, and mode ofadministration and dose adjustment based on monitoring results to guide rational drug use behavior. Serum creatinine and blood urea nitrogen levels in patients were compared before and after the adjustment. Results Changes in plasma concentration after norvancomycin had a difference between the elderly patients and young patients（P〈0.05）. The serum creatinine and urine nitrogen levels were stabilizing after the mode ofadministration and dosage adjustment.Conclusion In the course ofelderly patients to vancomycin for treatment, the use oftherapeutic drug monitoring can effectively guide clinical rational use ofdrugs to reduce the damage caused by the drug to the patient.

关 键 词：去甲万古霉素 血药浓度监测 合理用药 老年患者 

分 类 号：R964[医药卫生—药理学]