额叶肿瘤静息态功能磁共振比率低频振幅的研究  

Study of Tumor with Frontal Lobe by the Fractional Amplitude of Low Frequency Fluctuation of Resting-state Functional Magnetic Resonance Imaging

作　　者：赵翠花[1] 陶玲[1] 俞宙[1] 武江芬 孙金洋 周晖[1] 

机构地区：[1]南京航空航天大学自动化学院,南京210016

出　　处：《生物医学工程研究》2015年第1期11-14,22,共5页Journal Of Biomedical Engineering Research

基　　金：国家自然科学基金资助项目(61075107)

摘　　要：采用静息态下功能磁共振成像(f MRI)比率低频振幅(f ALFF)测量技术,从能量的角度对额叶肿瘤患者与正常对照组进行比较分析,探讨额叶肿瘤患者认知功能失调的病理机制。本研究分别对14例额叶肿瘤患者和14例性别、年龄及受教育程度均相匹配的健康对照组进行静息态f MRI扫描,用f ALFF算法进行比较分析。结果显示额叶肿瘤组同正常对照组相比,额叶肿瘤组f ALFF值升高的脑区主要集中在右侧眶额回、右侧颞叶、右侧辅助运动区、左侧海马旁回、左侧后扣带回、左侧内侧和旁扣带及旁中央小叶,f ALFF值降低的脑区主要集中在双侧背外侧额上回、双侧内侧额上回和小脑。研究结果显示在静息态下额叶肿瘤患者的额叶功能活动降低,这与额叶肿瘤部分组织的失活有关,而其余的默认网络区域、辅助运动区和旁中央小叶的活动增强,可能与额叶肿瘤脑认知功能失调及代偿作用有关。To investigate pathological mechanism of dysfunction of cognitive control in tumor in frontal lobe,using a resting- state functional magnetic resonance imaging（ f MRI） index,fractional amplitude of low frequency fluctuation（ f ALFF）. 14 patients with tumor in frontal lobe and 14 gender,age and education- matched healthy controls were experienced resting- state f MRI scans. f ALFF approach was used to analyze f MRI data in resting state. Compared with healthy control group,the group with frontal lobe tumor showed the increased value of f ALFF in the right orbitofrontal,right temporal lobe,right supplementary motor area,left parahippocampal gyrus,left posterior cingulate gyrus,the left medial cingulate and paracentral lobule,in the bilateral dorsolateral frontal gyrus,bilateral medial frontal gyrus and Cerebelum. The results show the decreased functional activity in the frontal area of the resting state in the patient＇ s tumor in frontal lobe,which is part of the frontal lobe tissue of the inactivation of tumor,whereas the rest of the default mode network regions and the enhancements of supplementary motor area may be related to cognitive dysfunction and compensatory effect.

关 键 词：静息态 功能磁共振 比率低频振幅 额叶肿瘤 默认网络 

分 类 号：R318[医药卫生—生物医学工程]