伊立替康的用药风险与合理用药  

Medication risk and rational use of irinotecan

作　　者：王喆[1] 李萌[1] 朱小明[1] 

机构地区：[1]解放军总医院第一附属医院药剂药理科,北京100048

出　　处：《实用药物与临床》2015年第4期451-453,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的分析伊立替康在临床使用中出现的不良反应(ADRs)及用药合理性,促进临床安全用药。方法检索近5年国外有关伊立替康ADRs的文献报道,进行分析整理。结果伊立替康的ADRs主要为胃肠道反应、血液系统、神经系统、皮肤及附件损害等,严重时可导致死亡。结论临床医务人员应及时处理伊立替康引起的ADRs,增加患者的依从性、耐受性,以保证临床用药安全。Objective To analyze the adverse drug reactions（ ADRs） and rational use of irinotecan,and promote the safety drug use. Methods Case reports and literatures about irinotecan-induced ADRs in abroad in recent five years were analyzed and summarized. Results The main adverse reactions of irinotecan were gastrointestinal reaction,hematologic toxicity,neurotoxicity,damages of skin and its appendages and so on,and the serious ADRs could lead to death. Conclusion Clinical medical personnel should cope with ADRs induced by irinotecan,in order to improve the compliance and tolerance of patients and guarantee the safety of clinical drug use.

关 键 词：伊立替康 不良反应 合理用药 

分 类 号：R96[医药卫生—药理学]