利用果蝇动物模型研究运动抗心脏衰老的分子机制  

Research on the Molecule System of Anti-aging-heart by Sports through Using Drosophila Animal Model

作　　者：吴越[1] 郑澜[2] 

机构地区：[1]黄冈师范学院体育学院,湖北黄冈438000 [2]湖南师范大学体适能与运动康复湖南省重点实验室,湖南长沙410012

出　　处：《科教文汇》2015年第11期185-186,共2页Journal of Science and Education

基　　金：国家自然科学基金课题(项目号:31071039)

摘　　要：适宜规律的运动训练可以延缓心脏功能的生理性衰退,但其分子机制未知。目前采用哺乳动物模型研究这一机制存在诸多困境。果蝇的生命周期短、遗传背景简单、转基因技术成熟,一直是衰老基因筛选和功能研究的理想模式生物,得益于近年果蝇抗重力攀爬系统的开发,本文将依托前期实验成果阐述果蝇运动模型的建立方法与可行性,同时结合果蝇心脏功能检测技术说明果蝇运动模型研究抗心脏衰老分子机制的发展前景和局限性。Sports and training based on proper rules can slow the physiological decline of cardiac function, but it＇s molecule system is unknown. Currently, there are various problems in the use of mammal model to research the system. Short life cycle, simple genetic background, and mature transgenic technology of drosophila, make it an ideal model for aging gene screening and function research, which benefits from the development of the anti-gravity climbing system of drosophila in recent years. Relying on previous experiment results, this paper will elaborate the feasibility and construction method of drosophila movement model, and combined with the testing technology of drosophila cardiac function, introduce the development prospect and limitation of the molecule system of anti-aging-heart by sports through using drosophila movement model.

关 键 词：果蝇运动模型 分子机制 心脏功能 衰老 

分 类 号：G804.2[文化科学—运动人体科学]