高原康胶囊对模拟高原急性缺氧大鼠尿量的影响及机制探讨  

Effect and Mechanism of Gaoyuankang Capsules on Urine Volume of Rats with Simulated Acute Hypobaric Hypoxia

作　　者：孙创斌[1] 刘国清[1] 陶朝阳 王建军[1] 李素芝[1] 

机构地区：[1]西藏军区总医院药物制剂研究中心,西藏拉萨850007

出　　处：《解放军药学学报》2015年第2期93-95,共3页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：国家科技部"重大新药创制"专项基金;No.2011ZXJ09105B

摘　　要：目的观察高原康胶囊在模拟高原低氧环境下对大鼠尿量的影响,并探讨其对肾素-血管紧张素(Ang)-醛固酮(ALD)系统的作用。方法采用模拟海拔5000 m的高原低氧环境制备大鼠急性缺氧模型。实验分6组:平原组、高原组、螺内酯组、高原康高、中、低(80、40、20 mg·kg^(-1))3个剂量组,用代谢笼法测各组大鼠24 h内的总尿量,取血测定血浆中AngⅡ和ALD含量。结果高原康胶囊组大鼠尿量均明显增多,血浆中AngⅡ和ALD的含量明显降低,与高原组比较有显著性差异(P<0.05)。结论高原康胶囊有明显的利尿作用,其机制可能与其作用于肾素-血管紧张素-醛固酮系统有关。Objective To observe the effect of Gaoyuankang capsules on rats＇ urine volume in a simulated high-altitude hypoxic environment, and to explore the role in the rennin-angiotensin （Ang）-aldosterone （ALD） system （RAAS）. Methods A acute hypoxic model was prepared for rats using a simulated high-altitude hypoxic environment of 5000 meters. Rats were divided into 6 groups ： the plain group, simulated high-altitude group, spironolactone group, and Gaoyuankang capsules groups （ 80,40,20 mg · kg^-1 ）. The total 24 h urine volume of rats was measured in a metabolic cage, and the levels of Ang Ⅱ and ALD in plasma were determined. Results Compared with the high-altitude group, the urine volume of rats in Gaoyuankang groups was significantly increased, while the levels of Ang Ⅱ and ALD in plasma were significantly decreased （ P 〈 0.05 ）. Conclusion Gaoyuankang capsules have significant diuretic effect, and the mechanism may be related to RAAS

关 键 词：高原康胶囊 模拟高原 急性缺氧 血管紧张素 醛固酮 

分 类 号：R965.1[医药卫生—药理学]