济生肾气丸质量标准的研究  

Quality Standard for Jisheng Shenqi Pills

作　　者：胡丹[1,2] 曹红[2] 水彩红[2] 陈玉敏[2] 单婷婷[2] 张贵英[2] 

机构地区：[1]第二军医大学药学院,上海200433 [2]总后勤部卫生部药品仪器检验所,北京100166

出　　处：《解放军药学学报》2015年第2期120-122,共3页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：国家重大科学仪器设备开发专项项目;No.2012YQ18013208

摘　　要：目的建立济生肾气丸的质量标准。方法采用TLC法对山茱萸药材进行鉴别;HPLC法同时测定莫诺苷、马钱苷与丹皮酚3种成分的含量。结果山茱萸的TLC鉴别方法简单可行;莫诺苷、马钱苷和丹皮酚与其他色谱峰得到良好的分离,平均回收率分别为98.58%、101.31%和100.17%,RSD分别为1.88%、1.67%和1.55%。结论该方法简便、准确,重复性好,可用于控制该产品质量。Objective To establish a standard for quality control of Jisheng Shenqi pills. Methods TLC was used for the identification of Comus. The content of morroniside, loganin, paeonol was determined by HPLC. Results Comus could be detected by TLC. Morroniside, loganin and paeonol were well separated under the chromatographic condition. The average recovery was 98.58% （ RSD = 1.88% ） for morroniside, 101.31% （ RSD = 1.67% ） for loganin and 100.17% （ RSD = 1.55% ） for paeonol. Conclusion This method is simple, accurate and reproducible for quality control of the preparation.

关 键 词：济生肾气丸 质量标准 莫诺苷 马钱苷 丹皮酚 

分 类 号：R927.2[医药卫生—药学]