薄荷醇对磷酸川芎嗪微乳透皮性质的影响  

Study on the gelatinization of ligustrazine phosphate microemulsion and its transdermal characters

作　　者：陈卓[1] 崔颖[2,3] 

机构地区：[1]武警总医院医疗事故技术鉴定工作办公室,北京100039 [2]武警后勤学院药物化学教研室,天津300309 [3]天津市职业危害与防制重点实验室,天津300309

出　　处：《武警后勤学院学报（医学版）》2015年第3期176-178,共3页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：【目的】研究薄荷醇对磷酸川芎嗪微乳体外透皮特性的影响。【方法】采用立式Franz扩散池法考察不同浓度薄荷醇对磷酸川芎嗪微乳体外渗透曲线及参数的影响。【结果】加入3%和5%薄荷醇微乳的透皮吸收曲线更加弯曲,提示微乳的迟滞时间均延长(P<0.05),3%和5%的薄荷醇能够显著增加磷酸川芎嗪透皮速率分别至108.41和119.21μg·(cm2·h)-1(P<0.01),但是1%的薄荷醇对迟滞时间和透皮速率没有显著影响。【结论】薄荷醇呈非浓度依赖性促进磷酸川芎嗪微乳透皮吸收。[Objective] To study the effects of different thickening agents on ligustrazine phosphate microemuMon and in vitro transdermal characters of the microemulsion gel. [Method]The effects of different macromolecular thickening agents on microemulsion were studied with magnetic stirring method, and the transdermal curves and parameters of ligustrazine phosphate microemulsion by Aerosil 200 in different concentrations were investigated with FRANZ diffusion method. [ Result]The transparent gel was prepared only with the application of Aerosil 200 in ligustrazine phosphate microemulsion without destruction of microemulsion structure. The viscosity increased to 62.19, 87.35,116.47,127.81,153.45 Pas at Aerosil 200 concentrations of 3%, 4%, 5%, 6%, 7%, while the transdermal flux decreased to 95.69, 77.76, 59.48 μg ＂ （cm2 · h）- 1 with the increase of Aerosil 200 concentration from 4 to 6%. [Conclusion] In general consideration of transparent gel structure, suitable viscocity and transdermal flux, ligustrazine phosphate microemulsion with 5% Aerosil 200 was the optimal choice.

关 键 词：磷酸川芎嗪 微乳 凝胶 透皮速率 

分 类 号：R917[医药卫生—药物分析学]