国人Brugada综合征的临床分析  

Clinical study of Brugada syndrome in Chinese population

作　　者：孟娟[1] 雷娟[1] 方昶[1] 袁桂仪[1] 周淑娴[1] 

机构地区：[1]中山大学孙逸仙纪念医院心内科广东省心电生理和心律失常重点实验室,广东广州510120

出　　处：《中国心脏起搏与心电生理杂志》2015年第2期121-127,共7页Chinese Journal of Cardiac Pacing and Electrophysiology

摘　　要：目的探讨中国Brugada综合征的发病现状、临床特征和诊治情况。方法选择1998年1月至2013年6月在CNKI、万方数据库、维普数据库、Pubmed中以"Brugada"为自由词或关键词,检索国人发表的Brugada病例182例。采用回顾性方法,对资料进行汇总分析。结果 Brugada综合征患者男女之比14.7∶1,中位年龄41岁;25例有家族猝死史,5例有家族Ⅰ型Brugada波。72.3%有晕厥史,晕厥年龄(43.0±12.0)岁。39.0%记录到多形性室性心动过速/心室扑动/心室颤动。71例行心电生理检查,阳性率49.3%。药物激发试验阳性率为92.9%。10例误诊。埋藏式心脏转复除颤器(ICD)植入占指南推荐的19.8%。猝死率8.2%,猝死年龄(48.7±16.7)岁。结论近15年来中国报道182例Brugada综合征,其特点:累及年龄广,中青年为主,男性居多,晕厥为其最主要的临床表现,药物激发试验及心电生理检查阳性率高,治疗现状不规范,ICD植入率低,猝死率高。Objective To explore the clinical characteristics of Brugada syndrome in Chinese population by the retro- spective study. Methods From January 1998 to June 2013, 182 patients found from the cases reported in China with ＂Brugada＂ as the free word or keyword in the databases of CNKI, WAN FANG, VIP and Pubmed at the same time. Re- view all the related information of the eligible patients and cases in literatures. Results The ratio of men to women of Brugada was 14.7 ： 1. The median age is 41.0 years at the time on admission. Twenty-five cases had definite family histo- ries of sudden cardiac death. Five cases had coved-type ECGs in family members. The most common symptom was syncope （72.3 % ） with a mean age of 43.0 ± 12.0 years.. Ventricular fibrillation, ventricular flutter and polymorphic ventricular tachycardia were the most common presentations （39.0%）. Seventy-one patients were done with electrophysiological stud- y, and the positive rate was 49.3%. The positive rate of drug provocation test was 92.9%. Ten were missed diagnosis The rate of implantable cardioverter defibrillator（ICD） implantation was 19.8% according to the second consensus. The mortality was 8.2%, with a mean age of （48.7± 16.7） years. Conclusions In China, there are 182 patients of Brugada syndrome reported in recent fifteen years. Age of Brugada syndrome involved broadly, with high incidence of adults in Chi- na. The morbidity of male is preponderant. The most common symptom is syncope. The positive rates of drug provocation test and EPS are high. We have shortage to recognition at present. Therapy status is poor and the rate of ICD implantation is low.

关 键 词：心血管病学 BRUGADA综合征 发病现状 诊断 治疗 

分 类 号：R541.7[医药卫生—心血管疾病]