未成熟卵泡抽吸术联合二甲双胍对氯米酚抵抗PCOS患者疗效分析  

Curative effect analysis of immature follicle aspiration combined with metformin in the treatment of clomiphene resistant PCOS patients

作　　者：戚静宜[1] 杜翠果[1] 王芳[1] 

机构地区：[1]郑州大学附属洛阳中心医院生殖医学科,471000

出　　处：《中国实用医药》2015年第9期3-5,共3页China Practical Medicine

基　　金：洛阳市科技发展计划项目(项目编号:1101050A)

摘　　要：目的探讨联合超声下未成熟卵泡抽吸术(IMFA)与二甲双胍对氯米酚抵抗的多囊卵巢综合征(PCOS)患者行促排卵前预处理对其卵巢反应性及治疗结局改善的有效性。方法 92例氯米酚抵抗的PCOS患者随机分成对照组和IMFA组,每组46例。对照组服用二甲双胍及口服避孕药预处理,IMFA组在口服药物的基础上进行未成熟卵泡抽吸术,比较两组促排卵治疗结局。结果两组预处理后IMFA组促性腺激素(Gn)量低于对照组,单卵泡发生率较对照组高(P<0.05)。两组妊娠情况差异无统计学意义(P>0.05),但IMFA组妊娠率升高,流产率降低。结论 IMFA可以有效改善氯米芬抵抗的PCOS患者的卵巢反应性,IMFA联合二甲双胍和口服避孕药在氯米芬抵抗的PCOS的治疗中提供了有效的新途径。Objective To explore the effectiveness of ultrasound immature follicle aspiration （IMFA） combined with metformin in pretreatment of clomiphene resistant polycystic ovary syndrome （PCOS）for ovarian response and improvement of treatment outcome. Methods A total of 92 patients with clomiphene resistant PCOS were randomly divided into control group and IMFA group, and each group contained 46 cases. The control group received metformin and oral contraceptive for pretreatment, and the IMFA group received additional immature follicle aspiration. Outcomes of ovulation induction were compared between the two groups. Results After pretreatment, the IMFA group had lower gonadotropin （Gn） than the control group, and its incidence of single follicle was higher than the control group （P〈0.05）. The difference of gestation condition between the two groups was not statistically significant （P〉0.05）, while the IMFA group had increased gestation rate and decreased abortion rate. Conclusion IMFA can effectively improve ovarian response in clomiphene resistant PCO.S patients. Combination of IMFA, mefformin and oral contraceptive provides a new method in the treatment of clomiphene resistant PCOS.

关 键 词：未成熟卵泡抽吸术 多囊卵巢综合征 氯米酚抵抗 二甲双胍 

分 类 号：R711.75[医药卫生—妇产科学]