儿童接种重组酵母乙型肝炎疫苗的免疫效果评价  

Children＇s yeast recombinant hepatitis b vaccine immunization effect assessment

作　　者：唐林锋 

机构地区：[1]浙江省乐清市翁洋街道社区卫生服务中心防保科,浙江乐清325600

出　　处：《医药前沿》2015年第7期56-57,共2页Journal of Frontiers of Medicine

摘　　要：目的：评价儿童接种重组酵母乙型肝炎疫苗的免疫效果。方法：采用随机整群抽样法选取489例接种重组酵母乙型肝炎疫苗儿童，接种后检测血清HBsAg、抗-HBs和抗-HBc水平，随访观察免疫效果。结果：本组489例儿童在免疫接种1年后和5年后的HBsAg阳性率、抗-HBc阳性率之间的差异无统计学意义（P〉0．05），免疫接种5年后的抗-HBs阳性率为33．95％，明显低于免疫接种1年后的93．56％，差异有统计学意义（P〈0．05）。结论：儿童接种重组酵母乙肝疫苗能够获得持久、有效的免疫效果，值得进一步推广使用。Objective Evaluation of children immune effect of yeast recombinant hepatitis b vaccine. Methods Selected by random cluster sampling method, 489 children with yeast recombinant hepatitis b vaccine inoculation after detection of serum level of HBsAg anti - HBs and anti - HBc, follow-up immune effect. Results In this group of 489 cases of children immunization and 1 year after five years of HBsAg positive rate, anti - HBc the difference between the positive rate of no statistical significance （P〉 0.05）, after five years in the immunization of anti - HBs positive rate was 33.95%, significantly less than 1 year after immunization of 93.56%, the difference was statistically significant （P〈 0.05）. Conclusions Children inoculated yeast recombinant hepatitis b vaccine can achieve lasting and effective immune effect, worthy of further promotion of use.

关 键 词：乙型肝炎 重组酵母乙型肝炎疫苗 儿童 预防接种 

分 类 号：R186[医药卫生—流行病学]