玉郎伞水提物对大鼠的长期毒性研究  

Study on Chronic Toxicity of Water Extract from Yulangsan in rats

作　　者：施之 陈春霞[1] 黄仁彬[1] 

机构地区：[1]广西医科大学药学院,广西南宁530021

出　　处：《医药前沿》2015年第8期23-27,共5页Journal of Frontiers of Medicine

摘　　要：目的：观察玉郎伞水提物对大鼠的长期毒性，为临床安全用药提供依据。方法：80只Wistar大鼠（雌雄各半）随机等分为对照组和玉郎伞水提物低、中、高剂量组（20、40、80g生药·kg-1·d-1，相当于人临床日拟用量的20、40、80倍），连续灌胃给药91天，停药后观察14天，对照组给以等体积蒸馏水。给药期及停药恢复期，观察大鼠的体征、行为、摄食量、排泄等一般状况及血液学、血液生化指标、脏体系数、病理组织学变化等。结果玉郎伞水提物对大鼠的一般状况、体质量增长、摄食量、血液学、血液生化指标、脏体系数、病理组织学变化无明显影响。结论：在本试验条件下，玉郎伞水提物在20、40、80g生药·kg-1·d-1属于安全剂量范围。Objective To observe the adverse effects and extent of long-term garage of Yulangsan on rats and to provide the reference for dinical use Mcthod Half male and female 80 Wistar rots were randomly divided into three treatment groups（Yulangsan water extract 20g/kg/day;, 40g/kg/day; 80g/kg/day of raw drug ） and a normal control group and then intragastric adminis[ration was given once a day for 91 days continuously. The normal control group was treated with the same volume of normal saline During the 14 days of adminisation and withdrawal recovey observe the general conditions of each rat like sign and behavior, food intake induding their secretions. At the end of the dosing period, 12 rats were randomly taken from each group （with half male and female）, then the blood serum was talken After that they were sacrificed and detect the hematology,, blood biochemistry and measure the liver indesc At the end of the recovery period, the remaining rats in each group will also sacrificed in the same matter. Result No obvious abnormalities was found on Yulangsan water extract low, medium and high groups （although there is statis cally significance on serum level, blood biochemistry and liver index but still in the normal control range） Conclusion Under the experimental conditions, Yulangsan water extract shows no significance adverse reaction upon crude drug dose under 20g/kg/ day, 40g/kg/day, 80g/kg/day of raw drug （80 gluer kg per day of raw drugs）.

关 键 词：玉郎伞 水提物 大鼠 长期毒性 

分 类 号：R965[医药卫生—药理学]