短期胰岛素泵强化治疗对初诊Ⅱ型糖尿病患者胰岛β细胞功能的影响  

Hort-term insulin pump intensive trearment was to Ⅱ diabetes islet beta cell function

作　　者：陈袁[1] 赵倩[2] 李显文[2] 

机构地区：[1]遵义市第一人民医院内分泌科,贵州遵义563000 [2]遵义医学院附属医院,贵州遵义563000

出　　处：《医药前沿》2015年第8期64-66,共3页Journal of Frontiers of Medicine

摘　　要：目的：对初诊的Ⅱ型糖尿病患者进行短期胰岛素强化治疗，探讨其对Ⅱ型糖尿病患者胰岛D细胞功能的影响。方法：将35名初诊Ⅱ型糖尿病患者，进行短期胰岛素泵强化治疗。观察治疗前后空腹血糖（FPG）、餐后2h血糖（2hPG）、糖化血红蛋白（HbAlc）、空腹及餐舌胰岛素、C肽变化，HOMA胰岛素抵抗指数（HOMA—IR）和HOMA-β细胞功能指数（HOMA-β）。结果：1．撤泵次日FPG、2hPG、HOMA-IR均较治疗前减低，FC—P、2hC-P、HOMA—β较治疗前有所增高，P〈0．05，差异有统计学意义；2．BMI、TG、TC、LDL-C与胰岛素抵抗均存在正相关，且BMI的r值最大，相关性最强。结论：1．对初诊II型糖尿病患者进行短期胰岛素泵强化治疗，可快速解除葡萄糖毒性，减轻胰岛素抵抗，改善胰岛p细胞功能；2．BMI、TG、TC、LDL-C与胰岛素抵抗存在正相关，其中BMI相关性最强，BMI、血脂异常可能是导致胰岛素抵抗的较为重要的因素。Objective The new type Ⅱdiabetes of short-term insulin intensive treatment, discuss its Ⅱ islet beta cell function in patients with diabetes. Methods 35 new II with type 1 diabetes, short-term insulin pump intensive treatment. Were observed before and after treatment of fasting plasma glucose （FPG）, 2h postprandial blood glucose （2 HPG）, glycosylated hemoglobin （HbAlc）, fasting and postprandial insulin, C peptide, HOMA insulin resistance index （HOMA IR） and HOMA - beta cell function index （HOMA - beta）. Results 1. The day after off pump FPG, 2 HPG, HOMA - IR was reduced, the FC - E 2 hc - P, HOMA - beta is higher before treatment, P 〈 0.05, think that the difference was statistically significant; 2. The BMI, TG, TC, LDL - C there were positive correlation with insulin resistance, and BMI value of r is the largest, most relevant. Conclusion 1. The first diagnosis II short-term insulin pump intensive treatment with type 1 diabetes, can quickly remove glucose toxicity, reduce insulin resistance, improve the function of islet beta cells; 2. The BMI, TG, TC, LDL - C is positively correlated with insulin resistance, the strongest correlation with BMI, BMI, dyslipidemia may be more important factors lead to insulin resistance.

关 键 词：胰岛素强化治疗泵 初诊Ⅱ型糖尿病 Β细胞功能 

分 类 号：R587.1[医药卫生—内分泌]