溶胶-凝胶法制备含锶生物玻璃及其溶解性  

Sr-containing bioglass fabricated by sol-gel method and its solubility

作　　者：吕凝磊[1] 尹乒[2] 夏明[1] 冯芳芳[1] 李锟[1] 雷霆[1] 

机构地区：[1]中南大学粉末冶金国家重点实验室,长沙410083 [2]中南大学湘雅医院,长沙410008

出　　处：《粉末冶金材料科学与工程》2015年第2期296-303,共8页Materials Science and Engineering of Powder Metallurgy

基　　金：国家自然科学基金委员会创新研究群体基金资助项目(50721003);中南大学粉末冶金国家重点实验室开放基金资助项目

摘　　要：采用溶胶-凝胶法制备不同锶含量改性的生物玻璃(CaO-P2O5-SiO2-SrO),分别采用X射线衍射仪和扫描电子显微镜对样品的相成分和形貌进行分析,采用浸泡法研究不同锶含量的生物玻璃在三羟甲基氨基甲烷(Tris)和模拟体液(SBF)中的溶解行为和生物矿化。结果表明:锶取代部分钙制备的锶改性生物玻璃为非晶结构,锶掺杂没有改变生物玻璃的微观结构;含锶生物玻璃与纯生物玻璃一样,在Tris和SBF溶液中均表现出良好的生物活性,但含锶生物玻璃表现出更缓的溶解速率,并且随Sr含量增加溶解速率下降;同时,矿化生成的羟基磷灰石(HA)结晶性变差,表明Sr的加入可以有效地调控生物玻璃的溶解速率,使设计与制备一定溶解速率的生物玻璃成为可能。CaO-P2Os-SiOz-SrO based bioactive glasses containing different amount of Sr were prepared via colloidal sol- gel method. Surface characterization were evaluated by X-ray powder diffraction （XRD） and scanning electron microscope （SEM）. Solubility and in vitro bioactivity of bioglasses with different Sr contents were investigated by soaking them in Tris solution and simulated body fluid. The results show that the substitution of Sr for Ca in the glass composition does not change the microstructure of bioglass and the structure of the as-prepared Sr-doped bio-glasses is amorphous. The Sr-containing bioglasses exhibit bioactivity in Tris and SBF solution but slower dissolution rate, which progressively decreases with the increase of Sr amount. Furthermore, the apatite formed by biomineralization in SBF has poor crystallinity with increasing Sr content. Sr can effectively regulate the dissolution rate of bioglass, which makes it possible for the design ofbioglass with certain dissolution rate.

关 键 词：溶胶-凝胶法 生物玻璃 锶 溶解性 

分 类 号：TG139[一般工业技术—材料科学与工程]