盐酸伐昔洛韦与阿昔洛韦治疗儿童水痘疗效的临床观察  

Clinical Observation of Valaciclovir Hydrochloride and Acyclovir in the Treatment of Children with Chickenpox

作　　者：林菁[1] 朱炜春[1] 谭丽丽[1] 胡丹[1] 

机构地区：[1]广州市第八人民医院儿科,广东广州501440

出　　处：《辽宁医学院学报》2015年第2期64-65,共2页Journal of Liaoning Medical University (LNMU) Bimonthly

摘　　要：目的对比分析盐酸伐昔洛韦和阿昔洛韦治疗儿童水痘的临床疗效。方法选取我院2013年9月至2014年11月期间因水痘需住院治疗患儿90例,随机分为2组,每组45例,分别予以盐酸伐昔洛韦(观察组)和阿昔洛韦(对照组)进行治疗,比较两组治疗后临床疗效、疗效指数和不良反应情况。结果观察组治愈率80.0%高于对照组53.3%,总有效率97.8%高于对照组84.4%,疗效指数(0.86±0.31)高于对照组(0.53±0.29),差异均具有统计学意义(均P<0.05);观察组瘙痒消失时间(0.7±0.2)d、全部结痂时间(2.3±0.5)d、痂落自愈时间(5.4±1.0)d均短于对照组,差异均具有统计学意义(均P<0.05);观察组总不良反应率与对照组比较,差异无统计学意义(P>0.05)。结论盐酸伐昔洛韦治疗儿童水痘临床效果较好,疗效指数更高,症状体征消失快,且不良反应无异常增高,适合临床应用推广。Object To compare the clinical efficacy of valacyclovir hydrochloride and acyclovir in the treatment of children with chickenpox. Method 90 children hospitalized in our hospital for chickenpox from September 2013 to November 2014 were selected and randomly divided into two groups（ 45 cases in each group）. The two groups were respectively given valacyclovir hydrochloride（ the observation group） and acyclovir（ the control group）,the clinical efficacy,therapy index and adverse reactions of two groups after treatment were compared. Result In the observation group,the cure rate was 80. 0% which was higher than 53. 3% of control group;meanwhile the total efficiency in observation group is 97. 8% that was higher than 84. 4% of control group,and the efficacy index in observation group is 0. 86 ± 0. 31 which is higher than 0. 53 ± 0. 29 of control group. The differences were statistically significant（ P〈0. 05）. Itching disappearance time of observation group was（ 0. 7 ± 0. 2） d,all crusted time was（ 2. 3 ± 0. 5） d,scab off and self-healing time was 5. 4 ± 1. 0 d which were all shorter than the time of control group,the differences were statistically significant（ P〈0. 05）. The difference of total adverse reactions rates between observation group and control group was not statistically significant（ P〉0. 05）. Conclusion The treatment of valacyclovir hydrochloride in children with chickenpox proves clinically effective with higher efficacy index; signs and symptoms disappear quickly,and adverse reaction rate doesn＇t unusually increase. It＇s suitable for clinical application and promotion.

关 键 词：盐酸伐昔洛韦 阿昔洛韦 儿童 水痘 

分 类 号：R511.5[医药卫生—内科学]