依达拉奉联合丹红注射液治疗急性心肌梗死后缺血/再灌注损伤的临床效果  

Clinical effect of edaravone combined with Danhong injection in the treatment of ischemia-reperfusion injury after acute myocardial infarction

作　　者：王尚昆[1] 解群光 

机构地区：[1]江西省永丰县人民医院内三科,江西永丰331500 [2]江西省永丰县新型农村合作医疗管理局,江西永丰331500

出　　处：《中国当代医药》2015年第11期138-141,共4页China Modern Medicine

基　　金：江西省吉安市指导性科技计划项目(吉市科计字[2014]36号)

摘　　要：目的探讨依达拉奉联合丹红注射液治疗急性心肌梗死后缺血/再灌注损伤的临床效果。方法选取本院2011年1月~2014年10月收治的60例ST段抬高AMI（STEMI）患者作为研究对象,随机分为观察组与对照组,各30例。对照组给予抗血小板、调脂、尿激酶静脉溶栓、抗凝、美托洛尔、卡托普利、硝酸酯类等治疗,观察组在对照组的基础上给予依达拉奉、丹红注射液静脉点滴,疗程均为14 d。比较两组的冠状动脉血管再通率、肌酸激酶同工酶（CK-MB）水平、再灌注心律失常等心血管事件发生率。结果两组的血管再通率比较,差异无统计学意义（P〉0.05）。观察组的CK-MB峰值较对照组提前。观察组的再灌注心律失常和严重心力衰竭发生率、死亡率显著低于对照组,差异有统计学意义（P〈0.05）。结论依达拉奉联合丹红注射液治疗能够降低急性STEMI患者溶栓后缺血/再灌注损伤发生率,并能改善预后。Objective To explore the clinical effect of edaravone combined with Danhong injection in the treatment of ischemia-reperfusion injury after acute myocardial infarction. Methods 60 patients with ST-segment elevation myocardial infarction（STEMI） from January 2011 to October 2014 in our hospital were selected and randomly divided into the observation group and the control group,30 cases in each group.The control group was given the treatment of antiplatelet treatment,lipid regulation,urokinase thrombolysis,anticoagulation,betaloc,captopril,and nitrate esters,the observation group was treated with edaravone and Danhong injection on the basis of the control group.The course of treatment in the two groups lasted 14 days.The recanalization rate of coronary vessels,the level of creatine kinase-MB（CKMB）,the incidence rate of cardiovascular event like reperfusion arrhythmia in two groups was compared respectively.Results There was no statistical difference in vascular reperfusion rate between two groups（P〈0.05）. The peak value of CK-MB was in advance in the observation group in comparison with that in the control group.The incidence and mortality of reperfusion arrhythmia and severe heart failure in the observation group was lower than that in the control group,with significant difference（P〈0.05）. Conclusion Combination of edaravone and danhong injection can reduce the occurrence rate of ischemia-reperfusion injury after intravenous thrombolysis in patients with STEMI as well as improve the prognosis.

关 键 词：依达拉奉 丹红注射液 急性心肌梗死 缺血-再灌注损伤 

分 类 号：R542.22[医药卫生—心血管疾病]