戊酸雌二醇配伍抗早孕药物在稽留流产中的应用价值  

Application value of estradiol valerate combined with anti-early pregnancy drugs for missed abortion

作　　者：罗丽丽 

机构地区：[1]河南省平顶山市新华区人民医院妇产科,467000

出　　处：《中国现代药物应用》2015年第10期28-29,共2页Chinese Journal of Modern Drug Application

摘　　要：目的探讨戊酸雌二醇配伍抗早孕药物米非司酮及米索前列醇在稽留流产中的应用价值。方法孕周≤20周稽留流产患者48例,按入院先后顺序分成A、B两组,各24例。A组患者入院先口服戊酸雌二醇3 mg,3次/d,连服3 d,同时口服米非司酮100 mg,12 h 1次,共2次,第3天阴道上药米索前列醇200μg;B组患者不口服戊酸雌二醇,直接应用米非司酮和米索前列醇片,用法同A组。观察两组临床疗效。结果 A组米索前列醇用量、妊娠组织排出时间、妊娠组织排出后阴道出血量、完全流产率与B组相比,差异均有统计学意义(P<0.05)。结论戊酸雌二醇配伍米非司酮及米索前列醇应用于治疗稽留流产与单用米非司酮及米索前列醇相比可增加完全流产率,减少清宫率,戊酸雌二醇配伍米非司酮及米索前列醇治疗稽留流产,疗效可靠,值得推广。Objective To investigate the application value of estradiol valerate combined with anti-early pregnancy drugs mifepristone and misoprostol for missed abortion. Methods A total of 48 patients with missed abortion≤ 20 gestational weeks were selected and divided by their admission order into group A and group B, with 24 cases in each group. Group A received 3 mg of estradiol valerate through oral administration by 3 times/ d for 3 d and 100 mg of mifepristone once in 12 h for 2 times, and these patients received 200 p.g misoprostol in vagina on the third day. Group B received mifepristone and misoprostol tablets without taking estradiol valerate ahead. Curative effects of the two groups were observed. Results Comparisons between group A and group B of misoprostol dosage, pregnancy tissue discharge time, haginal bleeding volume after discharge, and complete abortion rate showed that there were statistically significant differences （P〈0.05）. Conclusion hnplement of estradiol valerate combined with mifepristone and misoprostol in treating missed abortion can increase complete abortion rate and reduce curettage rate, compared with application of mifepristone and misoprostol alone. This method provides reliable effects, and it is worth promotion.

关 键 词：药物流产 戊酸雌二醇 米非司酮 米索前列醇 稽留流产 

分 类 号：R714.21[医药卫生—妇产科学]