基于中药组分和“组分结构”理论的中药研究模式的探讨  

Discussion about research ideas of Chinese materia medica based on Chinese materia medica components and "composition structure" theory

作　　者：严红梅[1,2] 陈小云[1,2] 张振海[1] 郁丹红[1] 贾晓斌[1,2] 

机构地区：[1]江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028 [2]南京中医药大学,江苏南京210046

出　　处：《中草药》2015年第8期1103-1110,共8页Chinese Traditional and Herbal Drugs

基　　金：江苏省中医药领军人才专项(2006)

摘　　要：中药是临床中医学长期实践的产物,具有多成分、多环节、多靶点的整体作用特点。由于中药的复杂性,目前尚未形成系统科学的中药研究思路,这严重制约着中药现代化的发展。在中医药理论指导下,从药效物质基础、药理作用机制、结构优化、基于组分结构理论的质控研究、组分体内药动学研究5个方面进一步系统深入地阐述以组分为功能单位的中药研究新模式,以期为中药现代化发展提供新的参考。Chinese materia medica（CMM） is the product of long-term practice of clinical traditional Chinese medicine（TCM）,and it has the characteristics of overall effect of the multi-component and multilink multiple targets.Because of the complexity of CMM,it has not yet formed systematic and the scientific method for the TCM research,which seriously restricts the development of modernization of CMM.Under the guidance of TCM theory,we explore the study on the new mode of CMM whose components are divided into the functional units by the CMM research foundation of material basis,pharmacological mechanism,the structure optimization,and new idea on the CMM quality control based on composition structure theory and in vivo pharmacokinetic as well.

关 键 词：中药组分 中药现代化 物质基础 结构优化 药动学 

分 类 号：R284[医药卫生—中药学]