3-苯丙烯酸类化合物的合成研究  

Study on synthesis of 3-phenylacrylic compounds

作　　者：孟侠[1] 史天恩 黄志强[1] 刘秀杰[1] 

机构地区：[1]天津理工大学化学化工学院,天津300384

出　　处：《天津理工大学学报》2015年第2期61-64,共4页Journal of Tianjin University of Technology

摘　　要：3-苯丙烯酸类化合物,即肉桂酸类化合物,合成方法中以Perkin缩合法和Knoevenagel缩合法最为普遍,为了解两个反应在相关合成中的异同,本研究分别以间硝基苯甲醛和对硝基苯甲醛为起始原料,采用两个方法制得间硝基肉桂酸和对硝基肉桂酸;并分别经硫化钠和硫氢化钠将硝基还原为氨基制得间氨基肉桂酸和对氨基肉桂酸.实验结果表明,采用Knoevenagel法比Perkin法收率提高8.0%以上;采用硫化钠还原比采用硫氢化钠收率提高10%以上.3-Phenylacrylic compounds, namely cinnamon acids, Perkin and Knoevenagel are the most common reactions among synthetic methods. To understand similaries and differences in the relevant synthesis, m-Nitrobenzaldehyde and P-Nitrobenzaldehyde respectively as starting materials generated 3-Nitrocinnamic acid and 4-Nitrocinnamic acid, the nitro group was reduced to amino group by sodium sulfide and sodium hydrosulfide. The experimental results show that the yield of Knoevenagel is 8.0% higher than Perkin, reduction use sodium sulfide yield increased by 10.0% than the use of sodium hydrosulfide.

关 键 词：间硝基肉桂酸 对硝基肉桂酸 间氨基肉桂酸 对氨基肉桂酸 合成 

分 类 号：TQ463[化学工程—制药化工]