蓍草化学成分研究  

Study on chemical constituents of Achillea alpina

作　　者：陈筱清[1] 王萌[1] 张欣[1] 郭未蔚 吴霞[1] 

机构地区：[1]首都医科大学中医药学院中医络病研究北京市重点实验室,北京100069

出　　处：《中国中药杂志》2015年第7期1330-1333,共4页China Journal of Chinese Materia Medica

摘　　要：采用硅胶、凝胶和半制备液相等色谱方法对蓍草Achillea alpina L.地上部分进行化学成分研究。根据理化性质和波谱学方法鉴定化合物的结构分别为墙草碱（1）,8,9-dehydropellitorine（2）,（E,E）-2,4-undecadien-8,10-diynoic acid isobutylamide（3）,（E,E）-2,4-tetradecadien-8,10-diynoic acid isobutylamide（4）,sintenin（5）,4＇,5,7,8-四甲氧基黄酮（6）,猫眼草黄素（7）,芒柄花素（8）,aurantiamide（9）,金色酰胺醇酯（10）,artemetin（11）,半齿泽兰素（12）。化合物1~5为首次从该植物中分离得到,化合物6~10为首次从该属中分离得到。Twelve compounds were isolated from the aerial parts of Achillea alpina by column chromatographies on silica gel, Sephadex LH-20, and semi-preparative HPLC. The structures were elucidated on the basis of spectral analysis. The compounds were identified as pellitorine（1）, 8,9-dehydropellitorine（2）,（E,E）-2,4-undecadien-8,10-diynoic acid isobutylamide（3）,（E,E）-2,4-tetradecadien-8,10-diynoic acid isobutylamide（4）,sintenin（5）, 4＇,5,7,8-tetramethoxyflavone（6）, chrysoplenetin（7）, formononetin（8）, aurantiamide（9）, asperglaucide（10）, artemetin（11）, and eupatorin（12）. compounds 1-5 were isolated from this plant for the first time, and compounds 6-10 were isolated from the genus Achillea for the first time.

关 键 词：蓍属 蓍草 化学成分 生物碱 

分 类 号：R284.1[医药卫生—中药学]