高原康胶囊对模拟高原缺氧性肺动脉高压大鼠ATP酶活性的影响  

Effect of Gaoyuankang capsules on ATP enzyme activity in rats with hypoxic pulmonary hypertension

作　　者：孙创斌[1] 刘国清[1] 陶朝阳 王建军[1] 李素芝[1] 

机构地区：[1]西藏军区总医院药物制剂研究中心,拉萨850007

出　　处：《中国新药杂志》2015年第8期875-877,899,共4页Chinese Journal of New Drugs

基　　金：国家"重大新药创制"科技重大专项(2011ZXJ09105B)

摘　　要：目的:探讨高原康胶囊对模拟高原缺氧性肺动脉高压大鼠ATP酶活性的影响。方法:大鼠进入模拟海拔5 000 m的高原低氧环境,连续缺氧40 d,制备高原缺氧性肺动脉高压大鼠模型。实验分5组:平原对照组、模拟高原对照组、高原康胶囊高(80 mg·kg-1)、中(40 mg·kg-1)、低(20 mg·kg-1)3剂量组。缺氧最后3 d,分别灌服相应药物。末次给药后1 h,测定大鼠平均肺动脉压力(m PAP),并取全血及心脑组织、测定ATP酶活性。结果:高原康胶囊可显著降低缺氧性肺动脉高压大鼠的平均肺动脉压,并可升高心、脑组织Na+-K+-ATP酶、Ca2+-Mg2+-ATP酶活性,但对全血ATP酶作用不明显。结论:高原康胶囊具有提高缺氧性肺动脉高压大鼠心脑组织ATP酶活性的作用。Objective： To investigate the effect of Gaoyuankang capsules on ATP enzyme activity in rats with hypoxic pulmonary hypertension （HPH） induced by a simulated high altitude. Methods： Rat HPH were induced by continuous hypoxia for 40 days in simulated altitude environments of 5 000 meters. Rats were administered with Gaoyuankang capsules （80, 40 and 20 mg· kg^-1 ） for 3 days after high-altitude simulation. After last adminis- tration for 1 h, mean pulmonary arterial pressure （mPAP） , and ATP enzyme activity in blood and cardiovascular tissues were determined. Results： Gaoyuankang capsules significantly reduced average mPAP in HPH rats, and increased the activity of Na^＋ -K ^＋ -ATP and Ca^2＋ -Mg^2＋ -ATP enzymes in the heart and brain. However, it did not significantly affect the activity of ATP enzymes in the blood. Conclusion： Gaoyuankang capsules can improve ATP ac- tivity of heart and brain tissues in HPH rats.

关 键 词：高原康胶囊 模拟高原 缺氧 肺动脉高压 ATP酶 

分 类 号：R965[医药卫生—药理学] R972[医药卫生—药学]