转鼓式生物反应器中液相体系的流动性能  

Flow Properties of Liquid Phase Systems in a Rotating Drum Bioreactor

作　　者：谭通[1] 王智慧[1] 温树梅[1] 张庆华[1] 吴霞[1] 丛威[1] 

机构地区：[1]中国科学院过程工程研究所生化工程国家重点实验室,北京100190

出　　处：《过程工程学报》2015年第2期190-197,共8页The Chinese Journal of Process Engineering

基　　金：国家重点基础研究发展规划(973)基金资助项目(编号:2010CB630904);国家自然科学基金资助项目(编号:21206166);国家高技术研究发展计划(863)基金资助项目(编号:2012AA021303)

摘　　要：采用粒子示踪测速法在18 L转鼓式生物反应器中考察了转速和挡板数、挡板类型和粘度对转鼓流场的影响.结果表明,在低粘的自来水介质中,转速为4～12 r/min时,Y向平均分速度由0.029 m/s增加到0.053和0.064 m/s时,挡板重力提升能力不断增强,提高转鼓转速可促进全局混合.直挡板数由4增加到8时,挡板提升能力增强32.5%,且能获得更均匀的流场分布;与自来水体系相比,高粘度8 g/L黄原胶溶液体系中流场分布更均匀,剪切更温和.Particle image velocimetry was used to investigate the flow profile of rotating drum bioreactor influenced by rotational speed and lifters with different numbers and configurations in two viscosity systems of tap water （μ=-1mPa.s） and 8 g/L xanthan gum solution （r=-10.97 Pa,μ=1 180 mPa.s）. The results showed that for low viscosity water system, mean Yvelocity was increased from 0.029 to 0.053 and 0.064 m/s, and global mixing performance and lifters hoisting capacity was promoted with the rotational speed from 4 to 12 r/min. With the increase of lifter number from 4 to 8, a more uniform flow field was obtained, and lifters hoisting capacity promoted by 32.5%. Compared with tap water, a more uniform flow field with more moderate shear stress formed in high viscosity system of 8 g/L xanthan gum solution.

关 键 词：转鼓式生物反应器 粒子示踪测速法 挡板 转速 流场 

分 类 号：Q819[生物学—生物工程]