机构地区:[1]中国医学科学院北京协和医学院北京协和医院超声医学科,100730
出 处:《中华医学超声杂志(电子版)》2015年第3期35-40,共6页Chinese Journal of Medical Ultrasound(Electronic Edition)
摘 要:目的探讨直肠腔内弹性成像对直肠腺瘤恶变的诊断价值。方法 2011年1月至2013年5月,选取北京协和医院基本外科诊治的直肠腺瘤患者60例,均在术前行直肠腔内弹性成像弹性分级法(ES)及应变比值(SR)检查。计算组内相关系数(ICC)评估SR多次测量的重复性。对照手术病理结果,评估弹性分级法、应变比值的诊断价值。结果 60例直肠腺瘤中良性腺瘤20例,腺瘤恶变(直肠腺癌)40例。常规ERUS判断腺瘤恶变的敏感度、特异度、准确性、阳性预测值、阴性预测值分别为68%(27/40)、40%(8/20)、58%(35/60)、69%(27/39)、38%(8/21)。弹性分级法诊断腺瘤恶变的敏感度、特异度、准确性、阳性预测值、阴性预测值分别为85%(34/40)、70%(14/20)、80%(48/60)、85%(34/40)、70%(14/20)。SR测量中,直肠腺癌SR高于良性腺瘤SR(2.82±1.81vs 1.23±0.57),且两者差异有统计学意义(t=3.333,P<0.05)。单纯良性腺瘤和良性瘤伴重度不典型增生的SR分别与完全恶变病灶的SR相比较(1.26±0.84 vs 2.94±1.95;1.42±0.55 vs 2.94±1.95),差异均有统计学意义(t=2.619,P=0.013;t=2.415,P=0.021)。以1.240为最佳诊断临界点,SR判断直肠腺瘤恶变的敏感度、特异度、准确性、阳性预测值、阴性预测值分别为82%(33/40)、75%(15/20)、80%(48/60)、87%(33/38)、68%(15/22)。结论直肠腔内弹性成像可以较准确地诊断直肠腺瘤恶变,为临床手术方式选择提供可靠的术前影像学依据。Objective To assess the value of endorectal elastography in the diagnosis of malignant rectal adenoma. Methods Sixty patients referred to the department of basic surgery of Peking Union Medical College Hospital for the evaluation of rectal adenoma from January 2011 to May 2013 were included in this prospective cohort. All patients underwent elasticity score (ES) and strain ratio(SR) examine before operation. To evaluate the reproducibility of the strain-ratio measurements, the intraclass correlation coefficient (ICC) was calculated. Compared with final operational pathological results,the diagnostic values of elasticity score and strain ratio method were assessed. Results Histopathological result showed there were 20 adenomas and 40 adenocarcinomas. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of ERUS was 68%(27/40), 40%(8/20), 58%(35/60), 69%(27/39), 38%(8/21), respectively. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of elasticity score was 85%(34/40), 70%(14/20), 80%(48/60), 85%(34/40), 70%(14/20), respectively. The SR of adenocarcinomas was significantly higher than that of adenomas(2.82±1.81 vs 1.23±0.57, t=3.333, P 〈 0.05). The differences among the SR of benign adenoma, benign adenoma with severe atypical hyperplasia and completely malignant lesions were statistically significant (1.26±0.84 vs 2.94±1.95, 1.42±0.55 vs 2.94±1.95, t=2.619, 2.415, P=0.013, 0.021). When 1.240 was chosen as the best cut-off value of SR, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of strain ratio was 82%(33/40), 75%(15/20), 80%(48/60), 87%(33/38), 68%(15/22), respectively. Conclusion Endorectal elasotgraphy can accurately diagnose the malignant rectal adenoma, which can provide reliable preoperative imaging evidence for clinical operation mode.
分 类 号:R445.1[医药卫生—影像医学与核医学] R735.37[医药卫生—诊断学]
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