钠钙交换蛋白特异调控与相关临床疾病研究进展  

Advances in specifi c regulation of sodium-calcium exchanger and its related clinical disease

作　　者：祖源[1] 万丽娟[1] 龚燕平[1] 李春霖[1] 

机构地区：[1]解放军总医院老年内分泌科,北京100853

出　　处：《解放军医学院学报》2015年第4期393-395,F0003,共4页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(H2811;81373458)~~

摘　　要：钠钙交换蛋白是广泛存在于动物细胞膜上的一种离子转运蛋白,分为SLC8基因家族编码的钠钙交换蛋白(NCX)和SLC24基因家族编码的钾依赖的钠钙交换蛋白(NCKX)。新发现的线粒体NCLX由SLC8B1基因编码现被认为是NCX家族成员,对线粒体钙稳态起重要作用。NCX与心脑血管疾病、肿瘤、糖尿病关系密切;而NCKX参与光感、嗅觉、皮肤色素沉着、脑功能的调控。对钠钙交换蛋白的研究可为临床相关疾病的研究提供新思路。Sodium-calcium exchangers are widely expressed in animal cell membrane, which can be divided into two groups： the Na^＋/Ca^2＋ exchangers encoded by SLC8 gene family （NCX） and the K＋ dependent Na^＋/Ca^2＋ exchangers encoded by SLC24 gene family （NCKX）. A mitochondrial Na^＋/Ca^2＋ exchanger has recently been identified as NCLX protein, which is a gene product of SLC8B1, and it is now included in NCX family. NCLX plays an important role inmitochondrial calcium homeostasis. According to current studies, NCX is closely related with cardiovascular disease, cancer and diabetes; while NCKX participates in biological process like vision, olfaction, skin pigmentation and brain function. Researches focused on sodium-calcium exchanger can provide new ideas and new directions in clinic diseases.

关 键 词：钠钙交换蛋白 分子生物学 基因 

分 类 号：Q428[生物学—神经生物学] Q493[生物学—生理学]