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机构地区:[1]复旦大学上海市第五人民医院麻醉科,上海200240
出 处:《中国临床医学》2015年第1期73-75,共3页Chinese Journal of Clinical Medicine
基 金:上海市闵行区科学技术委员会基金资助项目(编号:2013MHZ032)
摘 要:目的:比较七氟醚及笑气麻醉对青年大鼠和老年大鼠空间认知能力的影响。方法:取12只老年大鼠(18月龄)和12只青年大鼠(3月龄),均随机分为麻醉组(给予1.0最低肺泡有效浓度的七氟醚、70%笑气、30%氧气,吸入4 h,n=6)和对照组(给予30%氧气,吸入4 h,n=6)。48 h后对各组大鼠进行连续6 d的Morris水迷宫空间学习记忆能力训练,训练结束后24 h进行空间探索实验。结果:七氟醚/笑气麻醉可引起老年大鼠空间认知能力的损害,而对青年大鼠的空间认知能力没有影响。结论:七氟醚/笑气麻醉对老年大鼠的空间认知能力造成损害,这可能与老年大鼠的脑组织对麻醉药物更加敏感有关。Objective:To compare the effects of sevoflurane and nitrous oxide anesthesia on spatial recognition in young and aged rats.Methods:Young(3 months,n=12)and aged(18 months,n=12)rats were divided randomly into anesthesia group(sevoflurane at 1 minimum alveolar concentration,70% nitrous oxide,30% oxygen,for 4 h,n=6)and control group(30%oxygen,for 4 h,n=6).After 48 h,training on spatial learning and memory(probe trial)were done in the Morris water maze for 6 days.Spatial exploration test was conducted at 24 h after training.Result:Sevoflurane and nitrous oxide exposure induced a significant deficit in spatial recognition in aged rats,but not young rats.Conclusions:A significant deficit in spatial recognition in aged rats can be induced by sevoflurane and nitrous oxide exposure,which may due to that the aged brain is more susceptible to anesthetic-mediated changes.
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