血清白介素-15水平与膝骨关节炎患者影像学改变程度的相关性  

The correlation of serum interleukin-15 and imaging change degree in patients with knee osteoarthritis

作　　者：俞叶军 骆幸才 毕丽娜[2] 

机构地区：[1]富阳市人民医院放射科,浙江富阳311400 [2]中国康复研究中心北京博爱医院内分泌科,北京100068

出　　处：《健康研究》2015年第2期164-165,170,共3页Health Research

摘　　要：目的探讨血清白介素-15(interleukin-15,IL-15)水平与膝骨关节炎患者影像学改变程度的相关性。方法选择102名膝骨关节炎(osteoarthritis,OA)患者为OA组,54名健康体检者作为对照组。采用酶联免疫吸附法测定血清IL-15水平;采用Kellgren-Lawrence(KL)标准评价膝骨关节炎患者影像学改变的程度。结果 OA组KL2级、KL3级、KL4级患者的血清IL-15水平较对照组显著升高(均P<0.05)。OA组患者血清IL-15水平与KL分级呈显著正相关(r=0.433,P<0.01)。结论膝骨关节炎患者血清IL-15水平与影像学改变程度呈显著正相关。Objective To understand any possible correlation of serum interleukin-15 （interleukin-15,IL-15） level to knee osteoarthritis （ OA） patients.Method 102 OA patients were chosen to be the experimental group and 54 healthy were chosen to be the control group. Serum IL-15 levels were determined by enzyme-linked immunosorbent assay. The radiographic disease severity of OA was assessed by Kellgren-Lawrence （ KL） grading system.The data obtained were then subjected to statistical analysis.Findings The serum IL-15 levels of the KL2 level, KL3 level, and KL4 level patients in the experimental group were significantly higher than those of the control group （P〈0.05）.The levels of serum IL-15 were found to be positively correlated with KL grading scores in the experimental group （r=0.433, P〈0.01）.Conclusion Serum IL-15 levels were associated with radiographic disease severity of OA patients.These results demonstrated that IL-15 might serve as a potential indicator of the severity and progression of knee OA.

关 键 词：血清 白介素-15 膝骨关节炎 影像学改变 

分 类 号：R816.8[医药卫生—放射医学]