静脉注射右旋糖酐铁治疗腹膜透析肾性贫血的效果观察  

Clinical effect of intravenous iron dextran on peritoneal dialysis patients with renal anemia

作　　者：郑磊[1] 熊子波[1] 王青[1] 罗琼[1] 熊祖应[1] 

机构地区：[1]北京大学深圳医院肾内科,518036

出　　处：《中国综合临床》2015年第5期401-403,共3页Clinical Medicine of China

基　　金：深圳市科技计划医疗卫生类项目（201203020）

摘　　要：目的探讨静脉注射右旋糖酐铁治疗腹膜透析肾性贫血患者的临床效果。方法选取2010年1月至2014年6月我院治疗的50例腹膜透析肾性贫血患者，随机分为对照组与观察组，每组各25例。观察组应用静脉注射右旋糖酐铁治疗，100mg／次，3次／周；对照组使用琥珀酸亚铁200mg／次，口服，3次／d。两组患者均需连续用药8周。对两组患者临床症状的变化以及治疗效果进行对比分析。结果两组患者治疗8周血红蛋白、红细胞计数、红细胞比体积、网织红细胞计数、总铁结合力、血清铁均显著优于治疗前（P〈0．05或P〈0．01）；观察组治疗8周（91．6±13．8）g／L、（3．4±0．4）×10^9／L、0．31±0．04、（1．7±0．6）％、（38．9±6．7）％、（525．9±81．4）μg／L显著优于对照组[（79．6±13．9）g／L、（3．0±0．7）×10^9／L、0．27±0．06、（1．4±0．6）％、（28．1±8．4）％、（377．2±107．2）μg／L]，差异有统计学意义（P均〈0．05）。治疗8周观察组总有效率80％（20／25）；对照组总有效率76％（19／25）；两者差异无统计学意义（x^2=4．364，P〉0．05）。观察组不良反应发生率为4％（1／25），对照组为8％（2／25），差异无统计学意义（x^2=4．895，P〉0．05）。结论腹膜透析。肾性贫血患者静脉注射右旋糖酐铁治疗，可有效地改善患者的临床症状，补充患者体内的铁剂量。Objective To investigate the clinical effect of intravenous iron dextran peritoneal dialysis patients with renal anemia. Methods Fifty cases of peritoneal dialysis patients with renal anemia in the Shenzhen Hospital of Peking University from Jan. 2010 to Jun. 2014 were randomly divided into control group and the observation group, and 25 cases in each group. Patients in observation group were given intravenous iron dextran at dose of 100 mg/time, and 3 times/week. Patients in control group were given ferrous succinate at dose of 200 mg/times orally, and 3 times/day. Both treatment period was eight weeks. Changes in clinical symptoms and treatment of the two groups of patients were recorded. Results After eight weeks treatment, the levels of hemoglobin（ Hb）, red blood cell count （ RBC ）, hematocrit （ Hct ）, reticulocyte count （ Ret ）, total iron binding capacity（TS） and serum iron（SF） in two groups were significantly better than before treatment（ P〈0. 05 or P 〈0.01 ）. The levels of Hb, RBC, Hct, Ret, TS and SF in observation group after treatment were （91.6± 13.8） g/L, （3.4±0. 4） × 10^9/L,0. 31±0. 04, （ 1.7±0. 6）%, （38.9±6. 7）% and （525.9±81.4） μg/L, significantly better than those of control group（ （ 79. 6 ± 13.9） g/L, （ 3.0±0. 7） × 10^9/L,0. 27±0. 06, （ 1.4 ±0. 6） %, （ 28. 1 ±8.4） % and （ 377.2 ± 107. 2 ） μg,/L ）, and the differences were statistically significant （ P 〈0.05 ） . Total effective rate of observation group were 80%（20/25） and 76%（19/25） in the control group. The difference was not statistically significant（ X2 = 4. 364, P〉0.05）. Adverse reactions in observed group was 4% （ 1/25 ） and 8% （2/25） in control group （X2 = 4. 895, P 〉 0. 05 ）. Conclusion The therapy of intravenous iron dextran on peritoneal dialysis patients with renal anemia can effectively improve the clinical symptoms, and supply iron for the patient.

关 键 词：静脉注射 右旋糖酐铁 腹膜透析 肾性贫血 

分 类 号：R556.305[医药卫生—血液循环系统疾病]