埃索美拉唑与奥美拉唑三联疗法在2型糖尿病合并胃溃疡中的效果比较  

Clinical efficiency of Esomeprazole and Omeprazole triple therapies on gastric ulcer patients complicated with type 2 diabetes mellitus

作　　者：孙辉[1] 孙涛[1] 李毅[1] 

机构地区：[1]海军总医院消化内科,北京100048

出　　处：《中国综合临床》2015年第5期437-439,共3页Clinical Medicine of China

摘　　要：目的比较埃索美拉唑与奥美拉唑三联疗法在2型糖尿病合并胃溃疡中的疗效。方法将我院收治的75例幽门螺杆菌（HP）阳性的2型糖尿病合并胃溃疡的患者随机分为A（39例）、B组（36例）。两组均给予降糖治疗，A组给予埃索美拉唑、阿莫西林克拉维酸钾分散片、克拉霉素治疗，B组给予奥美拉唑、阿莫西林克拉维酸钾分散片、克拉霉素治疗。观察两组的临床效果及HP根除率。结果A组患者的总有效率（97．44％，38／39）明显优于B组（80．56％，29／36），两组比较差异有统计学意义（x2=5．598，P=0．025），HP根除率（92．31％，36／39）明显优于B组（75．00％，27／36），差异有统计学意义（X2=4．172，P=0．041）。结论埃索美拉唑三联疗法对2型糖尿病合并胃溃疡的疗效优于奥美拉唑三联疗法，且更能有效根除HP，值得临床推广。Objective To compare the clinical efficacy of esomeprazole or omeprazole triple therapies on gastric ulcer patients complicated with type 2 diabetes mellitus. Methods Seventy-five patients with Hprelated gastric ulcer and type 2 diabetes mellitus were enrolled and were randomly divided into group A（ n= 39） and group B （n = 36）. Patients in group A were treated with esomeprazole, amoxicillin and clavulanate potassium dispersible tablets, Clindamyein. Patients in group B were treated with omeprasole, amoxicillin and clavulanate potassium dispersible tablets, Clindamycin. Patients in both groups were treated with hypoglycemic therapy. The efficacy and the Hp eradicate rate of the two groups were observed and compared. Results The cure effect in group A was 97. 44%（38/39） ,much better than that of group B（80. 56%（29/36） ;X2 =5. 598,P=0. 025）. The Hp eradicate rate in group A was 92. 31%, also much better than that of group B （75.00%; X2= 4. 172, P =0. 041 ）. Conclusion The clinical efficacy and the Hp eradicate rate of esomeprazole triple therapies on gastric ulcer patients eomplieated with type 2 diabetes mellitus is better than that of omeprazole triple therapies. Esomeprazole triple therapies and it is worthy of being clinically promoted.

关 键 词：埃索美拉唑 奥美拉唑 胃溃疡 糖尿病 阿莫西林克拉维酸钾分散片 克拉霉素 

分 类 号：R587.1[医药卫生—内分泌]