对苯醌与异烟肼的荷移反应及其应用研究  

Charge transfer reaction between isoniazid with p-benzoquinone and its application

作　　者：尚永辉[1] 孙家娟[1] 古元梓[1] 

机构地区：[1]咸阳师范学院化学与化工学院,陕西咸阳712000

出　　处：《化学工程师》2015年第4期6-7,19,共3页Chemical Engineer

基　　金：国家自然科学基金项目(21475113);陕西省科技计划项目(2012JQ2013);咸阳师范学院专项科研基金项目(11XS YK104)

摘　　要：通过研究对苯醌与异烟肼之间的荷移反应建立了测定异烟肼的新方法。实验发现：以乙醇为溶剂,保持60℃温度,对苯醌与异烟肼混合30min能产生较为稳定的荷移络合物,络合物在最大吸收波长440nm处的吸光度值与异烟肼浓度在4.115~109.72mg·L-1浓度范围内呈良好的线性关系,线性方程为A=13.829C（mg·L-1）＋0.3992（r=0.9962）,方法应用于异烟肼片中异烟肼含量测定,回收率为97.6%~105.7%,测定值的相对标准偏差小于4.52%。A new mehthod for determination of isoniazid by studying charge transfer of benzoquinone and iso-niazid.The experiment showed that stable charge transfer complex would be produced by mixing isoniazid and benzoquinone for 30 min under the conditions of with alcohol as solvent and temperature is 60℃.The complex showed good linear relationship of absorbance at the 440 nm with isoniazid concentration of 4.115~109.72mg·L-1,the linear equation is A=13.829C（mg·L-1）＋0.3992（r=0.9962）.The recovery is 97.6%~105.7%,the standard deviations is less than 4.52%.

关 键 词：荷移分光光度法 异烟肼 对苯醌 

分 类 号：O657.3[理学—分析化学]