不同类型房颤患者脂联素的变化  

Change of adiponectin levels in patients with different types of atrial fibrillation

作　　者：李洁琪[1] 彭红[1] 杨红萍[1] 张荣先[1] 李屏[1] 赵全敏[1] 周开碧[1] 雷天琼 

机构地区：[1]贵阳医学院附属医院心内科,贵州贵阳550004 [2]贵州省遵义市红花岗区计划生育服务站,贵州遵义563000

出　　处：《重庆医学》2015年第12期1640-1642,共3页Chongqing medicine

基　　金：贵州省优秀青年科技人才计划项目[黔科合人字(2011)25号]

摘　　要：目的探讨不同类型心房颤动(房颤)患者血浆脂联素(APN)和N末端B型脑利钠肽原(NT-proBNP)的变化。方法将234例研究对象分为4组:窦性心律组70例、阵发性房颤组52例、永久性房颤组62例和对照组50例(健康体检者),采用酶联免疫吸附试验测定血浆脂联素水平,并检测NT-proBNP水平。结果阵发性房颤组、永久性房颤组患者NT-proBNP显著升高,与对照组和窦性心律组比较,差异有统计学意义(P<0.05);对照组与窦性心律组比较差异无统计学意义(P>0.05);与阵发性房颤组比较,永久性房颤组NT-proBNP明显升高(P<0.05)。与对照组比较,窦性心律组脂联素水平明显降低(P<0.05),与对照组和窦性心律组比较,阵发性房颤组和永久性房颤组患者脂联素水平均显著升高(P<0.05),与阵发性房颤组比,永久性房颤组脂联素水平明显升高(P<0.05)。结论脂联素的水平可能与永久性房颤的反复发生有关。Objective To investigate the changes of plasma adiponectin and N-terminal pro-brain natriuretic peptide （NT- proBNP） levels in the patients with different types of atrial fibrillation （Af）. Methods TWO hundred and thirty-four research sub- jects were divided into 4 groups：sinus rhythm group （n=70）, paroxysmal Af group （n= 52）, permanent Af group （n= 62） and control group （n= 50）. The plasma adiponectin level was measured by the enzyme-linked immunosorbent assay （ELISA） and the NT-proBNP level was detected by chemiluminescence. 4 groups were comparable in age, gender, body mass index and basic disea- ses. Results The NT-proBNP level in the paroxysmal Af group and the permanent Af group was significantly increased compared with the sinus rhythm group and the control group, the difference was statistically significant （P〈0.05）, but the difference be- tween the sinus rhythm group and the control group had no statistical significanee（P〉0.05）. The NT-proBNP level in the perma- nent Af group was significantly increased compared with the paroxysmal Af group （P〈0.05）. Compared with control group, the adiponectin level in the sinus rhythm group was significantly decreased （P〈0.05）, which in the paroxysmal Af group and the per- manent Af group was significantly increased compared with the sinus rhythm group and the control group,the difference was statis- tically significant （P^0.05）. The adiponectin level in the permanent Af group was significantly increased compared with the parox- ysmal Af group （P^0.05）. Conclusion The adiponectin level could be related with the repeated occurrence of permanent Af.

关 键 词：脂联素 心房颤动 利钠肽 脑 心力衰竭 

分 类 号：R541.75[医药卫生—心血管疾病]