江苏省某地区自然绝经女性月经初潮年龄与MS的相关性分析  

Analysis on correlation between menarche age and metabolic syndrome among natural menopausal women in an area of Jiangsu province

作　　者：吴娴[1] 王伟[1] 章月蟾 杨亚军[2] 袁子宇[2] 王笑峰[1] 

机构地区：[1]复旦大学生命科学学院遗传工程国家重点实验室/现代人类学教育部重点实验室,上海200438 [2]复旦大学泰州健康科学研究院,江苏泰州225312

出　　处：《重庆医学》2015年第12期1669-1672,共4页Chongqing medicine

基　　金：国家科技支撑项目(2011BAI09B00)

摘　　要：目的探讨自然绝经女性月经初潮年龄与代谢综合征（Ms）的相关性。方法对江苏省泰兴地区7个行政村45～64岁已自然绝经的女性3204人进行问卷调查、体质测量和生化检测。将调查对象按照初潮年龄小于14岁、14～16岁、〉16岁分组，采用国际糖尿病联盟（IDF）（2005）的MS诊断标准，以及美国国家胆固醇教育计划成人治疗组第3次治疗报告（NCEPATPⅢ）2005年根据亚洲人改良的诊断标准，以Logistic回归分析初潮与MS的关联。结果该人群MS粗患病率为35．39％[IDF（2005）]和20．57％[-NCEP ATPIlI（2005）]；Logistic回归分析显示两种标准判断MS得出的结论一致，即月经初潮年龄较早（〈14岁）增加Ms的发生多因素调整后OR分别为1．41（1．10～1．82）和1．55（1．16～2．08））。月经初潮年龄较早显著增加女性中心型肥胖的风险，而月经初潮年龄较晚（〉16岁）与Ms无关。结论月经初潮年龄较早是MS风险因素，应对月经初潮年龄较早的已绝经女性加强健康宣教及防控。Objective To explore the correlation between menarche age and metabolic syndrome （MS） in natural menopause women. Methods Three thousand two hundred and four natural menopausal women aged 45-64 years old were selected from 7 ad- ministrative villages in Taixing area and performed the questionnaire investigation, physical measurements and biochemical tests. The respondents were divided into different groups of less than 14 years old, 15-16 years old and more than 17 years old according to the menarche age. The MS diagnostic standard by the International Diabetes Federation（IDF, 2005） and the modified diagnostic standard based on the Asian by the third treatment report of the national cholesterol education program adult treatment group （NCEP ATPⅢ ,2005） were adopted and the Logistic regression analysis was used for analyzing the correlation between menarche age and MS. Results The MS crude prevalence rate in this group was 35.39% （IDF,2005） and 20.57% （NCEP ATP Ⅲ,2005） ; the Logistic regression analysis showed that the conclusion by the two kinds of MS diagnostic standard was consistent,i, e. earlier menarche age （less than 14 years old） increased the MS occurrence[after multivariable adjusting OR= 1.41（1.10-1.82） and 1.55 （1.16- 2.08）],in addition, earlier menarche age also significantly increased the central obesity risk in women, while later menarche age （〉16 years old） had no correlation with MS. Conclusion The earlier menarcbe age is a risk factor of MS. So the health publici- ty and education, prevention and control on the menopausal women with earlier menarche age should be strengthened.

关 键 词：自然绝经 月经初潮 年龄因素 代谢综合征 肥胖症 

分 类 号：R589[医药卫生—内分泌]