广西地区艾滋病患者认知功能初步调查  

Preliminary survey on cognitive function of AIDS patients in Guangxi area

作　　者：叶显芬 陈子蓉[2] 赵婷婷[3] 

机构地区：[1]广西壮族自治区柳州市柳城县疾病预防控制中心公共卫生管理科,广西柳州545200 [2]广西医科大学第一附属医院神经内科,广西南宁530022 [3]广西医科大学公共卫生学院,广西南宁530021

出　　处：《重庆医学》2015年第12期1673-1675,共3页Chongqing medicine

基　　金：广西艾滋病防治重点实验室开放课题(gxlabpt201304)

摘　　要：目的了解广西地区艾滋病患者的认知功能。方法选择广西南宁市第四人民医院根据实验室确诊的艾滋病患者80例作为病例组；同时从陪同家属中选取近3个月内无可感染艾滋病病毒的危险行为，艾滋病病毒抗体检测阴性88例作为对照组，应用蒙特利尔认知评估量表（MoCA）的中文翻译版，对两组对象进行认知功能调查及评估。结果病例组总分为2～29分，平均（20．04土6．13）分，其中认知功能损害48例（60．00％）；对照组总分为17～29分，平均（25．02土2．98）分，其中认知功能损害6例（6．82％）。病例组MoCA量表总分、视觉与执行力、命名、延迟回忆、注意力、抽象能力及定向力项得分均低于对照组（P〈O．01）。两组对象在各得分段人员分布及比例方面比较，差异有统计学意义（P〈0．05）。对性别、年龄、文化程度3个因素进行了Logistic回归分析，只有文化程度是影响因素。结论艾滋病患者中存在不同程度的认知功能损害，文化程度可能是影响该量表得分的因素。Objective To understand the cognitive function of the patients with acquired immune deficiency syndrome（AIDS） in Guangxi area. Methods Eighty cases of AIDS confirmed by laboratory in the Nanning Fourth Peoplers Hospital were selected as the patients group;at the same time 88 individuals without the dangerous behaviors within 3 months which could cause human im- munodeficiency virus（HIV） infection and with negative anti-HIV antibody detection were selected from the accompanying family members as the control group. The Chinese translation version of the Montreal cognitive assessment scale （MoCA） was adopted to conduct the investigation and evaluation on the cognition function in the two groups. Results The total score span in the patients group was 2-29 points with the average of （20.04±6.13） points,of normal cognitive function and 48 cases（60.00%） of cognitive impairment ; the total score span in the control group was 17-29 points with the average of （25.02±2.98） points, of normal cogni- tive function and 6 cases（6.82%） of cognitive impairment. The scores of MoCA total score, visual and execution, naming, delayed recall, attention, abstraction and orientation in the patients group were lower than those in the control group, the differences between the two groups were statistically significant（P〈0.01）. The personnel distribution and proportion in the various score segmenta- tions had statistical differences between the two groups（P〈0.05）. The factors of gender,age and educational level were performed the Logistic regression analysis,the results showed that only the educational level was the influencing factor. Conclusion Different degrees of cognitive impairment exist in the AIDS patients and the educational level may be a factor affecting the scale score.

关 键 词：获得性免疫缺陷综合征 认知功能 蒙特利尔认知评估量表 危险因素 

分 类 号：R512.91[医药卫生—内科学]