179例艾滋病病毒感染者及艾滋病患者生存质量研究  

Quality of life of 179 patients infected with HIV

作　　者：隋丹丹[1] 林鹏[2] 陈抒豪[1] 宫艳华[1] 傅秋龙[3] 黄喜明[4] 

机构地区：[1]佛山市疾病预防控制中心,广东佛山528051 [2]广东省疾病预防控制中心 [3]佛山市禅城区疾病预防控制中心 [4]佛山市南海区疾病预防控制中心

出　　处：《华南预防医学》2015年第2期117-123,共7页South China Journal of Preventive Medicine

摘　　要：目的了解佛山市CD4^＋T淋巴细胞计数≤350个/mm^3的艾滋病病毒感染者及艾滋病患者（HIV/AIDS）的生存质量现况,探讨影响生存质量的相关因素,为HIV/AIDS提供针对性的干预措施。方法采用WHO QOL HIV-BREF量表对2013年10月至2014年3月在佛山市疾病预防控制机构或医疗机构进行随访的CD4^＋T淋巴细胞计数≤350个/mm^3的HIV/AIDS进行调查,并收集该人群在＂艾滋病综合防治信息管理系统＂上的相关信息,包括基本的人口学信息及相关影响因素,并采用多元线性回归分析方法进行生存质量的影响因素分析。结果本研究共调查HIV/AIDS179例,男性占72.07%,平均年龄为（39.56±11.65）岁,以30-39岁年龄组居多,占33.52%;文化程度以初中为主,占51.40%;婚姻状况以已婚有配偶为主,占51.40%;职业以有职业为主,占80.45%;50.28%的病例是HIV感染者,49.72%是艾滋病患者;非本市户籍者占64.25%;感染途径以异性性传播为主,占63.69%。调查对象在心理领域（13.17±2.72）、独立性（14.12±2.75）及社会关系领域（12.94±2.53）的得分均低于常模（均P〈0.01）,在精神支柱/信仰/宗教领域（14.29±3.06）的得分高于常模（P〈0.01）。多元线性回归分析结果显示,与生存质量有关的影响因素有性别、学历、是否本地户籍、感染途径、是否接受抗机会性感染药物治疗、是否获得宣传材料、是否接受抗病毒治疗及是否获得安全套（P〈0.05或P〈0.01）,其中输血/血制品感染的人群在生理领域、独立性和精神支柱/信仰/宗教3个方面的生存质量得分较低（偏回归系数分别为-4.67、-4.00、-7.24）。结论 CD4^＋T淋巴细胞计数≤350个/mm^3的HIV/AIDS其生存质量低于普通人群,且对该人群的生存质量的影响因素较多,应针对相应的领域制定相关的措施以提高HIV/AIDS的生存质量。Objective To know the quality of life（ QOL） and it＇s influencing factors among patients infected with HIV with CD4^＋T lymphocyte counts（ CD4 counts） ≤350 / mm^3 in Zhuhai City,so as to provide targeted interventions for HIV / AIDS. Methods Patients infected with HIV,whose CD4 counts were below 350 / mm^3 and who were followed up by Foshan Municipal Center for Disease Control and Prevention or medical institutions in Foshan from October 2013 to March 2014,were investigated by using WHO QOL HIV – BREF. Data of the patients including basic demographic information and related influencing factors were obtained from the ＂ Information management system for the prevention and control of HIV / AIDS＂. Influencing factors of quality of life were analyzed by using multiple linear regression analysis method. Results A total of 179 cases were investigated. The average age was（ 39. 56 ± 11. 65） years.Among all the cases,72. 07% were males; 33. 52% were aged 30-39 years; 51. 40% had educational background of junior high school; 51. 40% were married; 80. 45% were on the job; 50. 28% were HIVinfected and 49. 72% were patients with AIDS; 64. 25% were not residents registered in the city. Heterosexual contact was the main route of HIV transmission（ 63. 69%）. The average scores of the cases were lower than those of the general population in psychological domain（ 13. 17 ± 2. 72）,independence domain（ 14. 12 ± 2. 75）,and social relations domain（ 12. 94 ± 2. 53）（ P〈0. 01 for all）,but higher in spiritual pillar / religious faith domain（ 14. 29 ± 3. 06）（ P〈0. 01）. In multiple linear regression analysis,the related factors affecting the QOL were gender,education,local household registration,route of infection,receiving treatment of opportunistic infections,advertising materials,receiving highly active antiretroviral therapy,and access to condom use（ P〈0. 05 or P〈0. 01）. Especially the scores for HIV / AIDS patients infected through blood transfusion were lower in physical

关 键 词：HIV感染 CD4淋巴细胞计数 生活质量 因素分析 统计学 

分 类 号：R183.7[医药卫生—流行病学] R512.91[医药卫生—公共卫生与预防医学]