麻藤定喘微型灌肠剂对哮喘婴幼儿血清IgE、EOS及IL-4、IFN-γ调节的临床研究  

Clinical Research of Adjustments of Serum IgE,EOS,IL- 4 and IFN- γ Levels on Asthma Infants Treated by Matengdingchuan Microenema

作　　者：尹杉杉[1] 刘昌玉[2] 

机构地区：[1]中南民族大学 [2]湖北省中医院儿科,湖北武汉430061

出　　处：《湖北中医药大学学报》2015年第2期29-31,共3页Journal of Hubei University of Chinese Medicine

基　　金：湖北省科技攻关计划项目(2007AA301B10-2)

摘　　要：目的观察麻藤定喘微型灌肠剂对哮喘婴幼儿血清Ig E、EOS及IL-4、IFN-γ的调节水平,探讨其机理。方法 120例哮喘婴幼儿随机分为两组,治疗组给予定喘微型灌肠剂,对照组给予美普清口服,观察治疗后两组症状及体征消失时间,血Ig E、EOS及IL-4、IFN-γ的变化。结果两组疗效比较无显著性差异(P>0.05);治疗组咳嗽及肺部哮鸣音消失时间与对照组比较有显著性差异(P<0.05);治疗组在调节Ig E、EOS及IL-4、IFN-γ方面明显优于对照组(P<0.05)。结论麻藤定喘微型灌肠剂可通过调节患儿血中Ig E、EOS及IL-4、IFN-γ水平,减轻哮喘患儿的病理变化从而控制哮喘的发作。Abstracts：Objective To observe the adjustments of serum IgE, EOS, IL -4 and IFN -γlevels on asthma infant treatmenting by Matengdingchuan microenema,investigate its mechanism.Methods 120 cases were divided into two groups.The treatment group treated with Matengdingchuan microenema and the control group used Meptin.The symptoms and signs disappeared time were monitored and the blood IgE, EOS, IL -4 and IFN -γlevels were investigated.Results The clinical effect showed no significant difference between two groups（P 〉0.05）;the symptoms and signs disappeared time between two groups showed significantly different（P 〈0.05）; the blood serum IgE, EOS, IL -4 and IFN -γlevels in treatment group were better than the control group（P 〈0.05）.Conclusion Matengdingchuan mi-croenema may regulate blood IgE, EOS and IL -4, IFN -γlevels, reduce pathological changes in children with asthma to control asthma at-tacks.

关 键 词：婴幼儿哮喘 中医灌肠治疗 麻藤定喘微型灌肠剂 

分 类 号：R286.5[医药卫生—中药学]