冠心病患者Gas6、CD36检测的临床意义  

Clinical Significance of Serum Gas 6、CD36 in Patients with Coronary Heart Disease

作　　者：陈馨[1] 崔天盆[1] 姚群峰[2] 

机构地区：[1]武汉市第一医院检验科,湖北武汉430022 [2]湖北中医药大学,湖北武汉430065

出　　处：《湖北中医药大学学报》2015年第2期116-118,共3页Journal of Hubei University of Chinese Medicine

基　　金：武汉市卫生局科研课题(WX12C29);国家自然科学基金资助项目(81170035)

摘　　要：目的探讨冠心病患者血清中生长停滞特异性基因产物6(Gas 6)、CD36的变化及临床诊断意义。方法选择心血管内科100例冠心病患者作为冠心病组,其中包括稳定型心绞痛(SAP)31例,不稳定型心绞痛(UAP)29例,急性心肌梗死(AMI)40例。同时选择健康体检者40例作为对照组。采用ELISA法检测两组血清Gas 6、CD36浓度,并对结果进行统计学分析。结果冠心病组血清Gas 6、CD36均显著高于健康对照组,差异有统计学意义(P<0.01)。不稳定型心绞痛和急性心肌梗死组CD36水平较稳定型心绞痛明显升高。稳定型心绞痛、不稳定型心绞痛、急性心肌梗死组的Gas 6水平较正常对照组高,但组内比较差异无统计学意义(P>0.05)。结论检测血清中生长停滞特异性基因产物6、CD36的浓度水平对判断冠心病的发生发展过程及其指导治疗有着重要临床意义。Abstracts：Objective To study the changes and clinical significance of growth arrest-specific 6（Gas6）,CD36 in patients with coro-nary heart disease.Methods We have selected 100 cases with coronary heart disease out of the in-part patients in cardiovascular depart-ment as CHD group, in which there are 31 cases with SAP, 29 cases with UAP and 40 AMI patients.Mean while, 40 healthy people were chosen as the control group.The serumal concentration of Gas 6 and CD36 were detected in two groups separately, and the results were statis-tically analyzed.Results The serum concentration of Gas 6 and CD36 in CHD group were significantly higher than the control group, and the data has statistically significant（P0.05）.Conclusion Detecting the serumal concentration of Gas 6 and CD36 is very important to evaluate the development and progression of coronaty heart disease and its treatment.

关 键 词：冠心病 生长停滞特异性基因产物6 CD36 

分 类 号：R541.4[医药卫生—心血管疾病]