自由基清除剂预防创伤性异位骨化的实验研究  

Effect of Free Radical Scavenger on Prevention of Traumatic Heterotopic Ossification in Rabbits

作　　者：闵红巍[1,2] 刘克敏[1,2] 顾蕊[1,2] 徐峰[1,2] 韩新祚[1,2] 亓攀 

机构地区：[1]首都医科大学康复医学院,北京市100068 [2]中国康复研究中心北京博爱医院骨科,北京市100068

出　　处：《中国康复理论与实践》2015年第4期422-425,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：中国康复研究中心科研基金项目(No.2010-Q2);北京丰台区卫生系统科学研究项目(No.2014-丰台)

摘　　要：目的比较口服非甾体类抗炎药物(NSAIDs)和静脉应用自由基清除剂对创伤性异位骨化动物模型的疗效。方法 48只新西兰白兔随机分成对照组、NSAIDs组、自由基清除剂组和联合治疗组,每组各12只。建立创伤性异位骨化模型,NSAIDs组、自由基清除剂组和联合治疗组分别予口服吲哚美辛、静脉注射依达拉奉以及联合应用两药,对照组予生理盐水,共用药4周。分别于术后8周、12周行X线检查,观察各组异位骨化的发生率和严重程度。结果术后8周、12周,NSAIDs组异位骨化发生率为33.3%和41.7%,自由基清除剂组异位骨化发生率为43%和45.8%,联合治疗组异位骨化的发生率为29.2%和37.5%,对照组异位骨化的发生率为70.8%和75%。各治疗组异位骨化的发生率和严重程度均低于对照组(P<0.05),而各治疗组之间异位骨化的发生率和严重程度无显著性差异(P>0.05)。结论全身应用自由基清除剂可有效地预防异位骨化形成,其效果与NSAIDs相当。两者不存在协同作用。Objective To compare the effects of non-steroidal anti-inflammatory drugs（NSAIDs） and free radical scavengers（FRS） on formation of traumatic heterotopic ossification（HO） in rabbits. Methods 48 New Zealand rabbits were randomly divided into control group（n=12）, NSAIDs group（n=12）, FRS group（n=12） and combination group（n=12）. The model of traumatic HO was established, and the NSAIDs group, FRS group and combination group were administered indometacin intragastrically, edaravone intravenously and both, respectively, while the control group was administered normal saline for 4 weeks. The incidence and severity of HO were observed with X-ray8 and 12 weeks after modeling. Results 8 and 12 weeks after operation, the incidence of HO was 33.3% and 41.7% in the NSAIDs group,43.0% and 45.8% in the FRS group, 29.2% and 37.5% in the combination group, and 70.8% and 75.0% in the control group, respectively.The incidence and severity of HO in all the treatment groups were significantly less than those in the control group（P〈0.05）, and there was no significant difference among the treatment groups（P〈0.05）. Conclusion The systemic application of FRS may prevent the formation of HO effectively, similar with the NSAIDs. There is no synergistic effect between them.

关 键 词：创伤性异位骨化 自由基清除剂 预防 兔 

分 类 号：R68[医药卫生—骨科学]