注射用利福平治疗复治涂阳肺结核的近期疗效观察  

Observation of curative effect of rifampicin injection in the treatment of patients with bacterium positive retreated pulmonary tuberculosis

作　　者：席秀娥[1] 王明永[2] 万勇敢[1] 姚恒波[1] 

机构地区：[1]新乡医学院第一附属医院结核内四科,河南新乡453100 [2]新乡医学院检验系,河南新乡453100

出　　处：《临床肺科杂志》2015年第6期977-980,共4页Journal of Clinical Pulmonary Medicine

基　　金：河南省医学科技攻关计划项目(No 2011020103)

摘　　要：目的评价国产注射用利福平冻干粉针(维夫欣)治疗复治涂阳肺结核的临床疗效和安全性。方法将200例复治涂阳肺结核患者随机分为观察组和对照组各100例,所有患者均采用2HRZES/6HRE复治方案抗结核治疗,观察组在强化期使用注射用利福平,观察组和对照组分别有98例和96例完成治疗。比较两组的痰菌阴转率、病灶显效率、空洞闭合率及临床症状改善等方面的差异。结果 (1)强化期结束时和疗程结束时观察组痰菌阴转率分别为82.7%(81/98)和93.9%(92/98),对照组痰菌阴转率分别为65.6%(63/96)和81.3%(78/96),不同时期比较差异均有统计学意义(P值均<0.05);强化期治疗结束时观察组的病灶显效率及空洞闭合率分别为82.65%(81/98)和40.82%(40/98),高于对照组的[60.41%(58/96)]和25.00%(24/96)(P值均<0.05);疗程结束时观察组的病灶显效率及空洞闭合率分别为92.86%(91/98)和85.71%(84/98),高于对照组的[81.25%(78/96)]和72.92%(70/96)(P值均<0.05);观察组发热、咳嗽、咳痰等临床症状缓解时间较对照组短(P<0.05)。(2)观察组不良反应发生率为16.33%(16/98),明显低于对照组的29.17%(28/96)(P<0.05)。结论在复治涂阳肺结核的治疗中,强化期使用注射用利福平能提高痰菌阴转、病灶显效率及空洞闭合率,加快临床症状消失,药物不良反应少,有较好的临床应用价值。Objective To observe the efficacy of rifampicin injection in the treatment of patients with bacterium positive retreated pulmonary tuberculosis. Methods 200 patients with bacterium positive retreated pulmonary tuberculosis were randomly divided into the observation group （100 cases） and the control group （100 cases）. The basic conditions of the two groups were comparability. All patients received the therapy of 2HRZES/6HRE, and the observation group received rifampicin injection during the intensified therapy period. 98 cases in the observation group and 96 cases in the control group completed the treatment. Then comparisons were made between the two groups in the sputum tubercle bacillus conversion rate, focus improvement rate, cavity closing rate, and clinical symptom improvement. Results （1） At the end of intensified therapy period and the end of the whole therapy, the sputum tubercle bacillus conversion rate in the observation group was 82. 7% （ 81/98 ） and 93. 9% （ 92/98 ） respectively, which were significantly higher than those in the control group [65. 6% （63/96） and 81. 3% （78/96）] （P〈0. 05） . At the end of intensified therapy period, the focus improvement rate and the cavity closing rate in the observation group was 82. 65% （81/98） and 40. 82% （40/98） respectively, which were higher than those in the control group [60. 41% （58/96） and 25. 00% （24/96）] （P〈0. 05）. At the end of the whole therapy, the focus improvement rate and the cavity closing rate in the observation group was 92. 86% （91/98） and 85. 71% （84/98）, which were higher than those in the control group [81. 25% （78/96） and 72. 92% （70/96）] （P〈0. 05）. The disappearance time of clinical symptoms （ fever, cough and sputum） in the observation group was shorter than that in the control group. （2） The incidence of adverse drug reactions （ADRs） in the observation group was 16. 33% （16/98）, which was lower than that in the control group [29. 17% （28/96）].

关 键 词：注射用利福平冻干粉针 结核 肺 复治 治疗 

分 类 号：R521[医药卫生—内科学]