SP-A测定与新生儿呼吸窘迫综合征的相关性研究  

The study of association between levels of SP-A and neonatal respiratory distress syndrome

作　　者：张可刚[1] 李艳[1] 周广菊[1] 

机构地区：[1]山东省枣庄市妇幼保健院儿科,山东枣庄277100

出　　处：《中国现代医生》2015年第9期35-37,共3页China Modern Doctor

基　　金：山东省枣庄市科技发展项目(2013070)

摘　　要：目的探讨SP-A含量与新生儿呼吸窘迫综合征的关系。方法对我院出生的胎龄小于34周的早产儿,统一测定SP-A,按胎龄分组,计算各组SP-A含量,计算每组NRDS发生率;将发生呼吸窘迫综合征的患儿作为观察组,未发生的作为对照组,比较SP-A含量差异;计算早产儿呼吸窘迫综合征SP-A含量95%医学参考值。结果 98例早产儿有32例发生了NRDS,两组SP-A含量比较差异有统计学意义,推断早产儿发生NRDS SP-A含量医学参考值为11.68 ng/m L。结论 SP-A含量增加,NRDS发生率降低;胎龄增大,SP-A含量增大;发生与未发生NRDS的患儿的SP-A含量差异有统计学意义,推断早产儿发生RDS医学参考值为11.68 ng/m L,为以后临床工作中快速测定该值,预测发生NRDS,并进行早期应用PS制剂提供理论依据。Objective To study the relationship between levels of SP-A and the occurrence of premature infants with respiratory distress syndrome （RDS）. Methods The premature infants of gestational age 〈 34 weeks were collected in our hospital. The premature infants with RDS as the observation group, non as the control group, and the levels of SP-A were analyzed and compared between the two groups.And then the 95% medical reference range of levels of SP-A of premature infants with RDS was calculated by statistical methods. Results There was significant difference between the two groups（P〈0.01）, the 95% medical reference range of levels of SP-A of premature infants with RDS was 11.68 ng/mL. Conclusion The level of SP-A was significantly correlated between the occurrence of premature infants with RDS. The 95% medical reference range of levels of SP-A of premature infants provide the theory for the early application of pul- monary surfactant.

关 键 词：表面活性蛋白A 新生儿呼吸窘迫综合征 医学参考值 

分 类 号：R722.1[医药卫生—儿科]