全身炎症反应综合征患儿血浆脑钠肽浓度测定的临床意义  

The clinical significance of plasma B-type natriuretic peptide(BNP) for children with SIRS

作　　者：郝晓燕[1] 梁春莉[2] 

机构地区：[1]山西医科大学研究生学院,山西太原030001 [2]山西省儿童医院特需病区,山西太原030013

出　　处：《中国现代医生》2015年第9期41-43,共3页China Modern Doctor

摘　　要：目的探讨血浆脑钠肽（BNP）浓度在小儿全身炎症反应综合征临床分级及预后中的临床意义。方法 76例患儿分为全身炎症反应综合征组36例、脓毒症组22例、严重脓毒症18例,在入院后的第1天、第3天、第5~7天应用干式免疫荧光定量法测定其血浆BNP浓度。结果严重脓毒症患儿各时间点血浆BNP浓度均高于全身炎症反应综合征组及脓毒症组,差异有统计学意义（P〈0.05）;各组血浆BNP浓度第5~7天均低于第1天,差异有统计学意义（P〈0.01）。结论血浆BNP浓度的高低,尤其是其动态变化对判断全身炎症反应综合征患儿的病情轻重及其预后具有一定的临床指导意义。Objective To investigate and evaluate of the levels of plasma B-type natriuretic peptide （BNP） of children with SIRS in prognosis and risk stratification significance. Methods The study patients consisted of 76 children, in- cluding 36 children with SIRS, 22 children with sepsis and 18 children with severe sepsis. Quantitative immunocyto- chemistry and ELISA methods was used to detect plasma BNP of all the children in the first day,the third day and the fifth to seventh day. Results The levels of plasma BNP in children with severe sepsis were higher than those in the children with SIRS or sepsis （P〈0.05） ;The levels of plasma BNP in all group were decrease in the first day,the third day and the fifth to seventh day（P〈0.01）. Conclusion The level of plasma BNP is positively correlated with the severity and prognosis of children SIRS, especially dynamic change.

关 键 词：小儿全身炎症反应综合征 脓毒症 严重脓毒症 脑钠肽 

分 类 号：R605.977[医药卫生—急诊医学] R459.7[医药卫生—外科学]