亚临床甲状腺功能减低合并脂肪肝的代谢性危险因素分析  

An analysis on metabolic risk factors of subclinical hypothyroidism complicated with fatty liver

作　　者：许维娜[1,2] 张筱凤[3] 胡志宏 

机构地区：[1]浙江中医药大学 [2]杭州市五云山疗养院,浙江杭州310008 [3]杭州市第一人民医院消化内科,浙江杭州310006 [4]杭州市上城区小营街道社区卫生服务中心,浙江杭州310000

出　　处：《中国现代医生》2015年第9期56-59,共4页China Modern Doctor

基　　金：浙江省医药卫生科技计划(2013KYB221)

摘　　要：目的探讨亚临床甲状腺功能减低合并脂肪肝的检出率及代谢性危险因素分析。方法回顾性调查2013年份健康体检资料,采用病例对照研究方法对亚甲减与非亚甲减的代谢性危险因素进行比较;采用单因素t检验分析亚临床甲减组合并脂肪肝与不合并脂肪肝的代谢性危险因素的差异;进一步采用多因素Logistic回归分析方法预测不同的危险因素发生亚临床甲减合并脂肪肝的概率。结果体检人群亚临床甲减组在收缩压、舒张压、体重指数、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、尿酸7项均值高于非亚临床甲减组,差异有统计学意义(P<0.05);单因素分析结果发现,亚临床甲减合并脂肪肝者在年龄、体重、体重指数、甘油三酯、高密度脂蛋白胆固醇、尿酸6项指标与未合并脂肪肝者相比,差异有统计学意义(P<0.05);多因素Logistic回归分析结果发现,年龄[OR(95%CI)=1.13(1.00,1.28)]、体重[OR(95%CI)=1.38(0.72,2.65)]、甘油三酯[OR(95%CI)=5.78(1.87,17.92)]3项危险因素进入回归方程(P<0.05)。结论症状隐匿的亚临床甲减合并脂肪肝有增多趋势,亚临床甲减者面临包括增龄、超重及多个心血管代谢性风险因素,在亚临床甲减合并脂肪肝的慢病管理策略中需重点解决减重、调脂、控制尿酸问题。Objective To explore the detection rate and metabolic risk factors of subclinical hypothyroidism complicat- ed with fatty liver. Methods A retrospective investigation was carried out for the data of health examination in 2013, and metabolic risk factors were compared between subclinical hypothyroidism and non-subclinical hypothyroidism via the case-control study method; the single-factor t-test was applied to analyze the differences of metabolic risk factors between subclinical hypothyroidism group complicated with fatty liver and the group not complicated with fatty liver; the multi-factor Logistic regression was further applied to predict the incidence of subclinical hypothyroidism combined with fatty liver caused by different risk factors. Results Among people taking physical examination, average levels of 7 indices in subclinical hypothyroidism group, including systolic pressure, diastolic pressure, BMI, triglyceride, total cholesterol, tow density lipoprotein cholesterin and uric acid, were higher than those in the non-subclinical hypothy- roidism, and the differences were statistically significant （P〈0.05）; Results of single-factor analysis showed that com- pared with patients with subclinical hypothyroidism not complicated with fatty liver, the differences of 6 indices of age, weight, BMI, triglyceride, high density lipoprotein cholesterin and uric acid in patients with subclinical hypothyroidism complicated with fatty liver were statistically significant （P〈O.05）; Results of multi-factor Logistic regression analysis found that 3 risks factors of age [OR （95%C/）=1.13 （1.00, 1.28）], weight [OR （95%C/）=1.38 （0.72, 2.65）] and triglyc- eride [OR （95%C/）=5.78 （1.87, 17.92）] were in the regression formula. Conclusion Subclinical hypothyroidism compli- cated with fatty liver with obscure symptoms has an increasing trend. Patients with subclinical hypothyroidism is faced with multiple cardiovascular metabolic risk factors including aging and overweight. Strategies of chronic dis

关 键 词：亚临床甲状腺功能减低 脂肪肝 

分 类 号：R581.2[医药卫生—内分泌] R575.5[医药卫生—内科学]