糖痹宁颗粒治疗糖尿病周围神经病变临床疗效及其对机体氧化应激的影响  

Clinical therapeutic effect of Tangbining granule in the treatment of diabetic peripheral neuropathy and on oxidative stress

作　　者：郭志芹[1] 贾文魁[1] 郭亚丽[1] 杨秀萍[1] 李晶[1] 张靖[1] 

机构地区：[1]山西中医学院中西医结合医院内分泌科,山西太原030013

出　　处：《中国现代医生》2015年第10期126-129,共4页China Modern Doctor

基　　金：山西省卫生厅科研课题计划(201201089)

摘　　要：目的观察糖痹宁颗粒治疗糖尿病周围神经病变阳虚血瘀证型临床疗效以及对机体氧化应激的影响。方法选择糖尿病周围神经病变阳虚血瘀证型患者,在对照组基础上加服糖痹宁颗粒,以中医症候积分为疗效判定标准,观察糖痹宁颗粒治疗糖尿病周围神经病变(DPN)有效性、安全性,同时观察治疗前后机体氧化应激指标超氧化物歧化酶(SOD)以及丙二醛(MDA)的改变。结果对照组总有效率70.37%,治疗组总有效率92.59%,两组相比差异有统计学意义(P<0.05);对照组治疗前后SOD及MDA变化无统计学差异,治疗组治疗前后SOD以及MDA变化有统计学差异,且治疗组与对照组相比治疗后SOD以及MDA变化有统计学差异。两组均未发生不良反应。结论应用自拟糖痹宁颗粒治疗糖尿病周围神经病变阳虚血瘀证患者疗效确切,同时改善了机体的氧化应激,无不良反应发生。Objective To observe the clinical curative effect of Tangbining granule in the treatment of diabetic periph-eral neuropathy syndrome of Yang deficiency and blood stasis type and the effect on oxidative stress. Methods selec-tion of diabetic peripheral neuropathy in patients with syndrome of Yang deficiency and blood stasis type, on the basis of the control group adds the clothing Tangbining granule, with symptom scores as the criterion of curative effect ob-servation of sugar,Tangbining granule in the treatment of diabetic peripheral neuropathy （DPN）effectiveness,safety,and observed before and after treatment with indicators of oxidative stress in the body superoxide dismutase enzyme（SOD）and malondialdehyde（MDA）changes. Results The total efficiency of the control group 70.37%,the total effec-tive rate of treatment group was 92.59%,there was significant difference between two groups （P〈0.05）; the SOD and MDA changes of the control group had no significant difference before and after the treatment, the SOD and MDA changes of the treatment group before and after treatment were statistically differences,and there was significant differ-ence in the change of MDA and SOD after treatment between two groups. There was no adverse reaction in two groups. Conclusion Tangbining granule in the treatment of diabetic peripheralneuropathy with Yang deficiency and blood stasis syndrome has exact curative effect,at the same time can improve oxidative stress in the body,without adverse reaction.

关 键 词：糖痹宁 糖尿病周围神经病变 氧化应激 

分 类 号：R259.872[医药卫生—中西医结合]