髓源性抑制细胞在类风湿关节炎中的研究进展  

Research progress on myeloid-derived suppressor cells in rheumatoid arthritis

作　　者：李东仕 郑若婷 林素娟[1] 陈式仪[2] 陈慎仁[2] 

机构地区：[1]汕头大学医学院,广东省在读硕士研究生515041 [2]汕头大学医学院第二附属医院内分泌风湿病科,广东省515041

出　　处：《中华临床医师杂志（电子版）》2015年第8期125-129,共5页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：髓源性抑制细胞(MDSCs)是一群免疫异质性细胞,通常在肿瘤、慢性炎症和骨髓移植等病理状态下出现扩增,在机体免疫系统中起调节作用。对MDSCs的研究早期集中在肿瘤方面,近年来对自身免疫性疾病研究逐渐增多。本文综述MDSCs的来源、不同分型功能、作用机制及与类风湿关节炎关系的相关研究。Myeloid derived suppressor ceils （MDSCs） are a heterogeneous population of cells that expand during tumor, chronic infection, marrow transplantation and other pathological conditions, and are responsible for regulating immune responses. The earliest researches about MDSCs focused on oncology field. In recent years, the researches about MDSCs in aotuimmune diseases is increasing. In this review, the origin, subsets and mechanisms of MDSCs, as well as the relationship between MDSCs and rheumatoid arthritis were discussed.

关 键 词：关节炎 类风湿 髓源性抑制细胞 

分 类 号：R593.22[医药卫生—内科学]