IgM肾病的研究现状  

The current research status of IgM nephropathy

作　　者：熊建琼[1] 杜晓刚[1] 

机构地区：[1]重庆医科大学附属第一医院肾内科,400042

出　　处：《中华临床医师杂志（电子版）》2015年第8期129-132,共4页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：IgM肾病指肾组织免疫荧光检查发现系膜区有弥漫性IgM沉积(IgM是唯一或最主要的沉积成分),光镜下可见肾小球系膜细胞增殖或肾小球结构基本正常的原发性免疫复合物介导的肾小球疾病。临床上可发生于任何年龄,儿童多见,多数以肾病综合征起病,少数表现为蛋白尿、单纯血尿或蛋白尿合并血尿,血清Ig M升高。目前研究提示,IgM肾病预后不容乐观。基于其病因和发病机制不清,其病理特点也不尽相同,临床表现也多种多样。该文将主要介绍IgM肾病的病因和发病机制、组织和病理特点、临床表现、诊断、治疗及预后等情况。IgM nvphropathy refers that kidney immunofluorescence examination found IgM diffusely deposites mesangial area （IgM is the only or the main composition）, and light microscopy can find glomerular mesangial cell proliferation or basic normal glomerular structure of primary glomerular disease mediated by primary immune complexes. IgM nephropathy can happen at any age, mostly in children, most with ncphrotic syndrome, a few of proteinuria, simple hcmaturia or proteinuria with hematuria, and elevated serum IgM. Current studies suggest that the IgM nvphropathy prognosis is not optimistic. Based on its etiology and pathogenesis is not clear, its pathological characteristics are also different, clinical manifestations are also varied greatly. The etiology and pathogenesis, the pathological characteristics, the clinical manifestations, diagnosis, treatment and prognosis, and etc. of IgM nephropathy were mainly introduced in this article.

关 键 词：肾病综合征 肾病 脂性 肾功能衰竭 慢性 IGM肾病 

分 类 号：R692[医药卫生—泌尿科学]