高容量连续性血液净化治疗对脓毒血症致早期急性肾损伤的效果分析  

Effect analysis of high volume continuous blood purification therapy on early sepsis with acute kidney injury

作　　者：张婷婷[1] 杨自力[1] 苏伟[1] 杨智[1] 

机构地区：[1]广州市第一人民医院重症医学科,广州510180

出　　处：《中国当代医药》2015年第10期72-74,共3页China Modern Medicine

摘　　要：目的：探讨高容量连续性血液净化治疗对脓毒血症致早期急性肾损伤的效果。方法选择本院2013年1月-2014年1月收治的104例脓毒血症继发早期急性肾损伤患者为研究对象，随机分为观察组和对照组，各52例，在常规治疗基础上，观察组超滤率设定为70 ml/（kg·h），对照组设定为35 ml/（kg·h），比较两组患者临床治疗效果。结果观察组患者治疗后APACHEⅡ评分、血尿素氮、血清肌酐、降钙素原、白细胞介素-6、肿瘤坏死因子和C反应蛋白水平均低于对照组，肾功能恢复时间和ICU住院时间短于对照组，差异有统计学意义（P〈0.05）。结论高容量连续性血液净化可以更有效地治疗脓毒血症所致早期急性肾功能损伤，其滤过效果更强，可提高脓毒血症的临床治疗效果。Objective To investigate the effect of high volume continuous blood purification therapy on early sepsis with acute kidney injury. Methods 104 patients with early sepsis secondary to acute kidney injury were selected in our hospital from January 2013 to January 2014,they were randomly divided into observation group and control group,and there were 52 cases in each group.On the basis of conventional therapy,the ultrafiltration rate of observation group was set at 70 ml/（kg·h）,the control group was set at 35 ml/（kg·h）,the clinical outcome between two groups was compared. Results APACHEII score,blood urea nitrogen,serum creatinine,procalcitonin,interleukin-6,tumor necrosis factor and C-reactive protein level in observation group was lower than that in control group respectively after treatment,renal function recovery time and ICU length of stay in observation group was shorter than that in control group respectively, with statistical difference （P〈0.05）. Conclusion High volume continuous blood purification can more effectively treat sepsis-induced acute renal injury in early,which filtering effect is stronger,can improve clinical outcomes for sepsis.

关 键 词：高容量连续性血液净化 脓毒血症 早期急性肾损伤 

分 类 号：R692[医药卫生—泌尿科学]