一种用于研究激光散斑血流成像方法的测试系统  

A measurement system to study the technique of laser speckle flowgraphy

作　　者：宋磊磊[1] 孔平 于小强[1] 李然[1] 杨晖[1] 

机构地区：[1]上海理工大学光电信息与计算机工程学院,上海200093 [2]医疗器械高等专科学校基础部,上海200093

出　　处：《光学仪器》2015年第2期107-110,115,共5页Optical Instruments

基　　金：国家自然科学基金资助项目(61007002);上海市研究生教育创新计划项目(SHGEUSST1301)

摘　　要：激光散斑血流成像(laser speckle flowgraphy,LSFG)技术也称激光散斑衬比分析(laser speckle contrast analysis,LSCA)技术,该技术采用一种无需扫描的全场光学成像方法,可对血流变化进行定量分析。激光散斑衬比分析方法可分为空间衬比、时间衬比及时空联合衬比三种分析方法,但已有研究中缺乏对三种不同衬比分析方法的应用范围及处理结果准确性等因素的综合分析。通过采用含有TiO2悬浮颗粒的液体流经软管模拟生物体血液流动变化的实验,介绍了激光散斑成像技术原理,并对空间、时间及时空联合衬比分析方法进行了对比分析,实现对不同速度之间各种衬比运算结果的比较。实验结果表明,时空联合衬比分析方法相比于单纯的空间衬比或单纯的时间衬比测试范围广,在保证较高的时间分辨率和空间分辨率的同时,减少了数据处理的运算量,提高了散斑衬比的准确性。Laser speckle flowgraphy(LSFG)technique,also known as laser speckle contrast analysis(LSCA),is a full field optical imaging method without scanning,which can quantitatively analyze the change of blood flow.LSCA method is commonly used in space,time and the ratio of contrast lining spatial-temporal speckle contrast analysis method.We analyze the applications and the accuracy of the previous researches,in which the analysis methods lack of three different contrast factors.Through the use of TiO2 containing suspended particles in the fluid through a hose simulated biological changes in the blood flow,we introduce the principle of LSFG technique,and compare the methods of space,time and spatial and temporal contrast analysis.We implement the various different speeds to compare the results of various contrast analysis methods.The experimental results show that the spatialtemporal contrast analysis method compared to the simple spatial contrast or the simple time contrast test range can guarantee the time resolution and high spatial resolution at the same time,reduce thecomputation of data processing,and improve the accuracy of the speckle contrast.

关 键 词：激光散斑 血流成像 时空联合 衬比分析 

分 类 号：O436[机械工程—光学工程]