葛根不同炮制品止泻作用研究  

Study on the Antidiarrheal Effects of Processed Products of Puerariae Lobatae Radix

作　　者：钟凌云[1] 马冰洁[1] 龚千锋[1] 

机构地区：[1]江西中医药大学药学院,南昌330004

出　　处：《江西中医药大学学报》2015年第2期75-76,90,共3页Journal of Jiangxi University of Chinese Medicine

基　　金：国家"十二五"科技支撑计划项目(2011BA104B05);江西省主要学科学术和技术带头人培养计划项目(20133BCB22006);江西中医药大学校级专项(2012EX3002)

摘　　要：目的:研究并比较葛根生品、麸煨葛根及清炒葛根的止泻作用,为葛根炮制品的临床用药提供客观实验依据。方法:采用胃排空及小肠推进率实验结合腹泻指数的测定,研究葛根生品、麸煨葛根及清炒葛根的止泻作用。结果:与空白组比较,葛根生品、麸煨葛根及清炒葛根在胃排空试验、小肠推进率及腹泻指数测定试验中均具有极显著性差异(P<0.01),各样品随给药剂量的增加,胃内残留率呈增强趋势、小肠推进率呈减弱趋势、腹泻指数呈降低趋势;而样品同剂量之间比较,胃内残留率由高到低为:麸煨葛根>清炒葛根>葛根生品,小肠推进率由高到低为:葛根生品>清炒葛根>麸煨葛根;腹泻指数由低到高:麸煨葛根>清炒葛根>葛根生品。结论:麸煨葛根止泻作用最强,结果为麦麸煨制葛根的临床应用提供试验依据。Objective：To provide experimental basis for clinical use of Puerariae Lobatae radix processing products by comparing the an-tidiarrheal effects of raw product, simmering by bran product and stir-frying product of Puerariae Lobatae radix.Methods：Gastric emptying, small intestinal propulsion rate test and diarrhea index were applied to determine the antidiarrheal effect of raw product, sim-mering by bran product and stir-frying product of Puerariae Lobatae radix.Results：Compared with blank group, the three samples of Puerariae Lobatae radix could extremely increase the gastric remnant rate, extremely decrease the rate of small intestine and the diar-rhea index（P〈0.01）with dose enhancement.Compared with the same dose, the order of the gastric remnant rate decrease, small in-testinal propulsion increase and diarrhea index increase is simmering by bran product, stir-frying product and raw product of Puerariae Lobatae radix.Conclusion：Simmering by bran product of Puerariae Lobatae radix showed the best effect of antidiarrheal.The results providing a better understanding of the clinical use of Simmering by bran product of Puerariae Lobatae radix.

关 键 词：葛根 麸煨葛根 清炒葛根 止泻 

分 类 号：R285.5[医药卫生—中药学]