聚乙烯醇/季铵盐壳聚糖复合水凝胶的制备及其烫伤敷料的应用  

The preparation of PVA/quaternized chitosan composite hydrogel and its application as artificial dressing for burn wound healing

作　　者：司徒方民[1] 赵巨鹏 邸勋 査振刚 屠美[2,3] 曾戎[2,3] 

机构地区：[1]暨南大学华文学院,广州510632 [2]暨南大学材料科学与工程系,广州510632 [3]人工器官及材料工程研究中心,广州510632 [4]暨南大学第一临床医学院,广州510632

出　　处：《功能材料》2015年第9期9133-9138,9143,共7页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(31170911);广东省高等学校科技创新重点资助项目(CXZD1015);暨南大学附属第一医院开放研究基金资助项目(511005024)

摘　　要：采用聚乙烯醇为基础材料,以季铵盐壳聚糖为抗菌剂,丙三醇为辅料,采用溶液共混法制备聚乙烯醇/季铵盐壳聚糖复合水凝胶作为皮肤烫伤敷料,通过流变实验、抗菌实验、细胞实验以及动物活体实验考察复合水凝胶的综合性能.结果表明,制备的复合水凝胶具有适宜的粘度（22-35Pa·s）,涂覆于皮肤表面呈现较好的粘附性能;对大肠杆菌和金黄色葡萄球菌均有良好的抑菌作用,同时具有优良的细胞相容性;复合水凝胶敷料对皮肤刺激极小,昆明鼠深Ⅱ度烫伤修复实验表明,凝胶敷料可有效加快创面愈合速度以及瘢痕的形成,创面愈合从-般的数周缩减至3周左右,大大缩短创面修复时间,且愈后瘢痕组织小.PVA/quaternized chitosan composite hydrogel as artificial dressing was prepared by solution blending method,in which,PVA was served as substrate,quaternized chitosan as antibacterial agent and glycerol as excipients.The combination properties of the composite hydrogel were studied via the rheological test,the antibacterial test,cytotoxic test and animal experiment.The results indicated that PVA/quaternized chitosan hydrogel possessed appropriate viscosity(22-35Pa·s),showed better adhesion performance when coated onto the skin.The composite hydrogel exhibited excellent inhibition effect to Escherichia coli and Staphylococcus aureus,caused only minimal irritation to skin and excellent cytocompatibility as well.The observations of deepⅡ degree burn repair test for Kunming mice revealed that the composite hydrogel was beneficial to healing of wound,formation of scar and shortening the healing time.

关 键 词：烫伤修复 复合水凝胶 敷料 聚乙烯醇 季铵盐壳聚糖 

分 类 号：O631.1[理学—高分子化学]