2型糖尿病患者血清脂肪细胞脂肪酸结合蛋白与阻塞性睡眠呼吸暂停综合征的相关研究  

Adipocyte fatty-acid binding protein associated with diabetes mellitus and obstructive sleep apnea syndrome

作　　者：戴丽芬[1] 郑静[1] 李郑芳[1] 宫芸[1] 曹立君[1] 程晓亮[1] 于南南[1] 

机构地区：[1]昆明医科大学第二附属医院内分泌科,云南昆明650101

出　　处：《云南医药》2015年第2期133-136,共4页Medicine and Pharmacy of Yunnan

摘　　要：目的探讨2型糖尿病(T2DM)患者血清脂肪细胞脂肪酸结合蛋白(A-FABP)与阻塞性睡眠呼吸暂停综合征(OSAS)的关系。方法选取门诊体检和住院患者63例,根据呼吸紊乱指数(AHI)分为正常对照组15例、单纯T2DM组16例、2型糖尿病并阻塞性睡眠呼吸暂停综合征(T2DM+OSAS)组32例。测定A-FABP,血糖,空腹胰岛素及相关生化指标,观察体重指数(BMI),腰臀比(WHR),对结果进行相关分析。结果三组之间的A-FABP,甘油三酯(TG),胆固醇(TC),高密度脂蛋白(HDL),低密度脂蛋白(LDL),空腹胰岛素(FINS),空腹血糖(FPG),餐后2h血糖(2h PG),糖化血红蛋白(HBA1C),HOAM抵抗指数(HOAM-IR)相比,其差异均有统计学意义(P<0.05);在T2DM并OSAS组中血清A-FABP与TC,LDL,FINS,2h PG,HBA1C呈正相关,与AHI,TG,FPG,HOAM-IR呈明显正相关,与HDL呈负相关;多元回归分析示:在T2DM组中TG,FPG进入方程,P<0.05,在T2DM并OSAS组中AHI,TG进入方程,P<0.01。结论在T2DM+OSAS患者中血清A-FABP显著高于单纯T2DM组和正常对照组,FPG,TG可能是T2DM人群中血清A-FABP水平的主要影响因素;在T2DM+OSAS患者中血清A-FABP与AHI和TG呈正相关,AHI,TG可能是血清A-FABP最主要的影响因素。Objective To investigate the association of serum adipocyte fatty acid binding protein with obstruc- tive sleep apnea syndrome in type 2 diabetes mellitus patients.Methods 63 cases of hospitalized patients and outpa- tients were divided into normal control group 16 cases,pure T2DM group of type 2 diabetes 15 cases,and obstructive sleep apnea syndrome （T2DM ＋ OSAS） group of 32 cases. Determinations of A-FABP, blood glucose, fasting insulin and related biochemical indicators, body mass index （BMI）, and waist hip ratio （WHR）were made,and results were an- alyzed.Results The differences between the three groups,A-FABP,triglycerides （TG）,cholesterol （TC）,high-density lipoprotein （HDL）,low density lipoprotein （LDL）,fasting insulin （FINS）, fasting plasma glucose （FPG）,blood sugar 2 hours after meal （2 HPG）, glycosylated hemoglobin （HBA1C）,HOAM resistance index （HOAM-IR）,had statistical sig- nificance（P〈0.05）.In T2DM and OSAS groups,the A-FABP and serum TC,LDL, FINS,2 HPG,and HBA1C were posi- tively correlated with AHI,TG,FPG,HOAM-IR,and negatively correlated with HDL.In multiple regression analysis, TG,FPG were into the equation in T2DM group（P〈0.05）,AHI,TG in T2DM and OSAS group were into the equation （P〈0.01）.Conclusion A-FABP serum in patients with T2DM＋OSAS is significantly higher than that of pure T2DM group and normal control group.Serum FPG and TG may be the main influencing factors.In patients with T2DM＋OSAS,A-FABP positively correlated with AHI and TG.AHI and TG may be the major influence factors in serum A-FABP.

关 键 词：脂肪细胞脂肪酸结合蛋白 2型糖尿病 阻塞性睡眠呼吸暂停综合征 

分 类 号：R587.1[医药卫生—内分泌]